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Review
. 2018 Jul;89(7):510-515.
doi: 10.1007/s00104-018-0626-1.

[Oligometastasis in pancreatic cancer : Current state of knowledge and spectrum of local therapy]

[Article in German]
F Gebauer  1 , A I Damanakis  2 , C Bruns  2
Affiliations
Review

[Oligometastasis in pancreatic cancer : Current state of knowledge and spectrum of local therapy]

[Article in German]
F Gebauer et al. Chirurg. 2018 Jul.

Abstract

Background: Several case series reported results of surgical resection in patients with pancreatic ductal adenocarcinoma in a metastasized stage.

Aim: A summarized overview of the current state of knowledge and a summary of the results of currently available studies.

Material and methods: A systematic search was carried out in MEDLINE and PubMed with respect to metastasized pancreatic cancer and surgical resection.

Results: The evidence level for surgical resection in the metastasized stage is weak and so far no prospective trials are available. The largest single-arm trial included 85 patients with hepatic metastasis. In cases of hepatic oligometastasis an overall survival of 11-14 months was observed. In the presence of pulmonary metastasis, overall survival seems to be prolonged compared to intra-abdominal metastasis, although the evidence level is relatively weak.

Conclusion: According to the available results, a general recommendation for surgical resection in a metastasized stage cannot be given; however, the results show a possible benefit for some well-selected patient subgroups. Prospective trials must validate these data and investigate the use of combined surgical and systemic treatments in the case of resectable metastatic pancreatic cancer.

Keywords: Ablative procedures; Hepatic metastasis; Multimodal therapy; Pulmonary metastases; Resection.

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