doi: 10.1016/j.ejmech.2018.03.038.
Epub 2018 Mar 14.
Synthesis of 3'-halo-5'-norcarbocyclic nucleoside phosphonates as potent anti-HIV agents
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- PMID: 29558735
- DOI: 10.1016/j.ejmech.2018.03.038
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Synthesis of 3'-halo-5'-norcarbocyclic nucleoside phosphonates as potent anti-HIV agents
Eur J Med Chem.
.
Abstract
The synthesis and the antiviral evaluation of 3'-halo (iodo and fluoro) 5'-norcarbocyclic nucleoside phosphonates is described. No antiviral activity was observed against Zika virus, Dengue virus 2, HSV-1, HSV-2 and Chikungunya virus. In contrast, some of the synthesized compounds are potent inhibitors of the replication of HIV-1, comparatively to (R)-PMPA, with no concomitant cytotoxicity.
Keywords: Antiviral; Carbocycle; HIV; Nucleoside analogues; Phosphonates.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.
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