Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jul;24(5):718-723.
doi: 10.1177/1076029618761006. Epub 2018 Mar 20.

Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation

Sallu Jabati  1 , Jawed Fareed  1 , Jeffrey Liles  1 , Abigail Otto  1 , Debra Hoppensteadt  1 , Jack Bontekoe  1 , Trung Phan  1 , Amanda Walborn  1 , Mushabbar Syed  2
Affiliations

Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation

Sallu Jabati et al. Clin Appl Thromb Hemost. 2018 Jul.

Abstract

The purpose of this study was to determine whether there are any differences in the levels of inflammatory, thrombotic, and collagen turnover biomarkers between individuals with atrial fibrillation (AF) and healthy volunteers. Circulating plasma levels of plasminogen activator inhibitor 1 (PAI-1), CD40-ligand (CD40-L), nucleosomes (which are indicators of cell death), C-reactive protein (CRP), procollagen III N-terminal propeptide (PIIINP), procollagen III C-terminal propeptide (PIIICP), procollagen I N-terminal propeptide, tissue plasminogen activator, and von Willebrand factor were analyzed as potential biomarkers of AF. Baseline plasma was collected from patients with AF prior to ablation surgery at Loyola University Medical Center. Individuals with AF had statistically significantly increased levels of PAI-1, CD40-L, and nucleosomes, when compared to the normal population ( P < .0001). Additionally, there was a statistically significant increase in the CRP ( P = .01), PIIINP ( P = .04), and PIIICP ( P = .0008) when compared to normal individuals. From this study, it is concluded that the prothrombotic, inflammatory, and collagen turnover biomarkers PAI-1, CD40-L, nucleosomes, CRP, PIIICP, and PIIINP are elevated in AF.

Keywords: atrial fibrillation; inflammation; thrombosis.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Comparison of the various collagen turnover biomarkers in patients with AF and in healthy controls. (A) demonstrates the comparison of PINP; (B) shows the comparison of PIIINP; and (C) shows the comparison of PIIICP. AF indicates atrial fibrillation; PAI-1, plasminogen activator inhibitor 1; PINP, procollagen I N-terminal propeptide; PIIICP, procollagen III C-terminal propeptide; PIIINP, procollagen III N-terminal propeptide.
Figure 2.
Figure 2.
Comparison of various of inflammatory and thrombotic biomarkers in patients with AF and in healthy controls. (A) demonstrates the comparison of nucleosomes; (B) shows the comparison of CRP; (C) shows the comparison of vWF; (D) shows the comparison of tPA; (E) shows the comparison of CD40-L; and (F) shows the comparison of PAI-1. AF indicates atrial fibrillation; CD40-L, CD40-ligand; CRP, C-reactive protein; tPA, tissue plasminogen activator.
Figure 3.
Figure 3.
Comparison of various biomarkers percent change from normal mean ± standard error of the mean. Data is already in Table 1, no need for the figure.
See this image and copyright information in PMC

References

    1. Naccarelli GV, Varker H, Lin J, Schulman KL. Increasing prevalence of atrial fibrillation and flutter in the United States. Am J Cardiol. 2009;104(11):1543–1549. - PubMed
    1. Collila S, Crow A, Petkun W, Singer D, Simon T, Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am J Cardiol. 2013;112(8):1142–1147. - PubMed
    1. Thacker E, McKnight B, Psaty BM, et al. Association of body mass index, diabetes, hypertension, and blood pressure levels with risk of permanent atrial fibrillation. J Gen Intern Med. 2013;28(2):247–253. - PMC - PubMed
    1. Zhao LQ, Liu SW. Atrial fibrillation in essential hypertension: an issue of concern. J Cardiovasc Med. 2014;15(2):100–106. - PubMed
    1. Harada M, Van Wagoner DR, Nattel S. Role of inflammation in atrial fibrillation pathophysiology and management. Circulation.2015;79(3):495–502. - PMC - PubMed