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. 2018 Mar 20;18(1):135.
doi: 10.1186/s12879-018-3014-z.

Adenovirus-associated acute conjunctivitis in Beijing, China, 2011-2013

Jie Li  1   2 , Xiaoyan Lu  3 , Baoming Jiang  3 , Yiwei Du  1   2 , Yang Yang  1   2 , Haikun Qian  1   2 , Baiwei Liu  1   2 , Changying Lin  1   2 , Lei Jia  1   2 , Lijuan Chen  4   5 , Quanyi Wang  6   7
Affiliations

Adenovirus-associated acute conjunctivitis in Beijing, China, 2011-2013

Jie Li et al. BMC Infect Dis. .

Abstract

Background: Human adenovirus (HAdV)-associated acute conjunctivitis is a common infectious disease and causes significant morbidity among residents in Beijing, China. However, little is known about the epidemiology and type distribution of acute adenoviral conjunctivitis in Beijing.

Methods: Acute conjunctivitis surveillance was conducted in 18 hospitals in Beijing from July through October during 2011-2013. HAdVs were detected by PCR from eye swab and types were determined by partial hexon and fiber gene sequencing. Risk factors associated with adenoviral conjunctivitis were analyzed.

Results: Of 876 conjunctivitis cases, 349 (39.8%) were HAdV positive. HAdV detection was most common in conjunctivitis patients aged 18-40 years; patients with contact history with a conjunctivitis case; patients with specimen collected on days 4-6 post symptom onset and patients who worked in food service as catering attendants. Fifteen types were identified among adenoviral conjunctivitis cases. Five HAdV types (HAdV-4, - 37, - 53, - 64 and - 8) accounted for 81.1% of all adenoviral conjunctivitis cases. HAdV-37, - 4 and - 53 were the most common types associated with adenoviral conjunctivitis in 2011, 2012 and 2013, respectively.

Conclusion: Multiple HAdV types were associated with acute conjunctivitis in Beijing. Predominant types associated with adenoviral conjunctivitis circulating in Beijing varied from year to year.

Keywords: Acute conjunctivitis; HAdV type; Human adenovirus.

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Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Ethics Committee and Beijing Center for Disease Prevention and Control. Written informed consent was obtained from the participants or the guardians if participants were under 16 years of age.

Consent for publication

Not applicable.

Competing interests

The authors declare that there are no conflicts of interest.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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