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Review
. 2018 Mar 20;22(1):73.
doi: 10.1186/s13054-018-1992-2.

Diaphragm dysfunction during weaning from mechanical ventilation: an underestimated phenomenon with clinical implications

Martin Dres  1   2 , Alexandre Demoule  3   4
Affiliations
Review

Diaphragm dysfunction during weaning from mechanical ventilation: an underestimated phenomenon with clinical implications

Martin Dres et al. Crit Care. .

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2018 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .

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Conflict of interest statement

Ethics approval and consent to participate

Not applicable

Consent for publication

Not applicable

Competing interests

Alexandre Demoule has signed research contracts with Medtronic, Maquet and Philips; he has also received personal fees from Medtronic, Maquet, Resmed, Fisher & Paykel and MSD. Martin Dres received personal fees from Pulsion Medical System and Lungpacer Inc.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Techniques to investigate diaphragm function in the ICU
Fig. 2
Fig. 2
Main factors contributing to diaphragm weakness before and on ICU admission and after exposure to mechanical ventilation
See this image and copyright information in PMC

References

    1. Thille AW, Cortés-Puch I, Esteban A. Weaning from the ventilator and extubation in ICU. Curr Opin Crit Care. 2013;19:57–64. doi: 10.1097/MCC.0b013e32835c5095. - DOI - PubMed
    1. Béduneau G, Pham T, Schortgen F, et al. Epidemiology of weaning outcome according to a new definition. The WIND study. Am J Respir Crit Care Med. 2017;195:772–783. doi: 10.1164/rccm.201602-0320OC. - DOI - PubMed
    1. Epstein SK, Ciubotaru RL, Wong JB. Effect of failed extubation on the outcome of mechanical ventilation. Chest. 1997;112:186–192. doi: 10.1378/chest.112.1.186. - DOI - PubMed
    1. Thille AW, Harrois A, Schortgen F, et al. Outcomes of extubation failure in medical intensive care unit patients. Crit Care Med. 2011;39:2612–2618. doi: 10.1097/CCM.0b013e3182282a5a. - DOI - PubMed
    1. Jung B, Moury PH, Mahul M, et al. Diaphragmatic dysfunction in patients with ICU-acquired weakness and its impact on extubation failure. Intensive Care Med. 2016;42:853–861. doi: 10.1007/s00134-015-4125-2. - DOI - PubMed

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