Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Mar 12:38:4.
doi: 10.1186/s41232-018-0061-1. eCollection 2018.

Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair

Kaoru Yamagata  1 , Shingo Nakayamada  1 , Yoshiya Tanaka  1
Affiliations
Review

Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair

Kaoru Yamagata et al. Inflamm Regen. .

Abstract

Articular cartilage has poor capacity for repair. Once damaged, they degenerate, causing functional impairment of joints. Allogeneic cartilage transplantation has been performed for functional recovery of articular cartilage. However, there is only a limited amount of articular cartilage available for transplantation. Mesenchymal stem cells (MSCs) could be potentially suitable for local implantation. MSCs can differentiate into chondrocytes. Several studies have demonstrated the therapeutic potential of MSCs in the repair of articular cartilage in animal models of articular cartilage damage and in patients with damaged articular cartilage. To boost post-implantation MSC differentiation into chondrocytes, the alternative delivery methods by scaffolds, using hyaluronic acid (HA) or poly-lactic-co-glycolic-acid (PLGA), have developed. In this review, we report recent data on the repair of articular cartilage and discuss future developments.

Keywords: Articular cartilage; Hyaluronic acid (HA); Mesenchymal stem cells (MSCs); Poly-lactic-co-glycolic acids (PLGA); Scaffold.

PubMed Disclaimer

Conflict of interest statement

Not applicable.Not applicable.Y. Tanaka, has received consulting fees, speaking fees, and/or honoraria from Daiichi-Sankyo, Astellas, Pfizer, Mitsubishi-Tanabe, Bristol-Myers, Chugai, YL Biologics, Eli Lilly, Sanofi, Janssen, UCB and has received research grants from Mitsubishi-Tanabe, Takeda, Bristol-Myers, Chugai, Astellas, Abbvie, MSD, Daiichi-Sankyo, Pfizer, Kyowa-Kirin, Eisai, Ono. S. Nakayamada, has received speaking fees from Bristol-Myers, UCB, Astellas, Abbvie, Eisai, Pfizer, Takeda and has received research grants from Mitsubishi-Tanabe, Novartis and MSD. K. Yamagata declares no conflict of interest.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

    1. Solheim E, Hegna J, Oyen J, Harlem T, Strand T. Results at 10 to 14 years after osteochondral autografting (mosaicplasty) in articular cartilage defects in the knee. Knee. 2013;20:287–290. doi: 10.1016/j.knee.2013.01.001. - DOI - PubMed
    1. Valderrabano V, Leumann A, Rasch H, Egelhof T, Hintermann B, Pagenstert G. Knee-to-ankle mosaicplasty for the treatment of osteochondral lesions of the ankle joint. Am J Sports Med. 2009;37:105S–111S. doi: 10.1177/0363546509351481. - DOI - PubMed
    1. Levy YD, Gortz S, Pulido PA, McCauley JC, Bugbee WD. Do fresh osteochondral allografts successfully treat femoral condyle lesions? Clin Orthop Relat Res. 2013;471:231–237. doi: 10.1007/s11999-012-2556-4. - DOI - PMC - PubMed
    1. Williams SK, Amiel D, Ball ST, Allen RT, Wong VW, Chen AC, et al. Prolonged storage effects on the articular cartilage of fresh human osteochondral allografts. J Bone Joint Surg Am. 2003;85-A:2111–2120. doi: 10.2106/00004623-200311000-00008. - DOI - PubMed
    1. Malinin TI, Mnaymneh W, Lo HK, Hinkle DK. Cryopreservation of articular cartilage. Ultrastructural observations and long-term results of experimental distal femoral transplantation. Clin Orthop Relat Res. 1994;303:18–32. - PubMed

LinkOut - more resources