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. 2018 Jan 4;9(16):12745-12753.
doi: 10.18632/oncotarget.23993. eCollection 2018 Feb 27.

Significant increased CA199 levels in acute pancreatitis patients predicts the presence of pancreatic cancer

Dongling Teng #  1   2 , Keyan Wu #  1   2 , Yunyun Sun #  1   2 , Min Zhang  1   2 , Dan Wang  1   2 , Jian Wu  1   2 , Tao Yin  2 , Weijuan Gong  1   2 , Yanbing Ding  1   2 , Weiming Xiao  1   2 , Guotao Lu  1   2 , Weiqin Li  3
Affiliations

Significant increased CA199 levels in acute pancreatitis patients predicts the presence of pancreatic cancer

Dongling Teng et al. Oncotarget. .

Abstract

Background and study aims: Carbohydrate antigen 19-9 (CA199) has been identified as a tumor marker for pancreatic cancer but also increases in benign lesions of the digestive system. However, literature associated with the relationship between CA199 and acute pancreatitis (AP) is limited. This study aimed to focus on serum CA199 level measurements in AP patients and the associated clinical significance.

Materials and methods: From January 2006 to December 2015, 1,609 consecutive patients with AP were admitted to our department and included in the study. The relationships among the etiology of AP, the disease severity, the incidence of pancreatic cancer during hospitalization and CA199 levels were analyzed.

Results: Serum CA199 levels were measured for 693 of 1,609 AP patients. Of those patients, 186 (26.8%) had elevated CA199 levels (> 37 U/ml). Patients with high CA199 levels were older and had predominantly biliary causes in comparison with patients with normal CA199 levels. There were no definite specific correlations between CA199 levels and disease severity in AP. In addition, serum levels of CA199 positively correlated with serum alanine aminotransferase, aspartate transaminase, glutamyl transpeptidase, alkaline phosphatase and creatinine levels. After stratification, the incidence of pancreatic cancer increased proportionally to CA199 levels in AP patients.

Conclusions: Serum CA199 levels was elevated in patients with AP, especially in patients with biliary pancreatitis. AP patients with significantly increased CA199 levels may have a higher risk for the presence of pancreatic cancer. We recommended routinely monitoring CA199 levels during hospitalization for AP patients.

Keywords: CA199; acute pancreatitis; pancreatic cancer; retrospective study.

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Conflict of interest statement

CONFLICTS OF INTEREST All authors have no conflicts of interest.

Figures

Figure 1
Figure 1. The distribution of CA199 in patients with greater than 37 U / ml levels
Figure 2
Figure 2. Comparison of serum CA199 concentrations by Atlanta classification, Ranson and CTSI score
Figure 3
Figure 3. Correlation between CA199 and other clinical indicators in AP patients
Figure 4
Figure 4. Dynamic changes of CA199 in AP patients
See this image and copyright information in PMC

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