Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec 25;9(12):6111-6119.
doi: 10.19082/6111. eCollection 2017 Dec.

Comparison of gastric juice soluble triggering receptor expressed on myeloid cells and C-reactive protein for detection of Helicobacter pylori infection

Ahmad Piroozmand  1   2 , Babak Soltani  3   4 , Mohsen Razavizadeh  5 , Amir Hasan Matini  6 , Gholam Abbas Moosavi  7 , Mohammad Salehi  8 , Siamak Soltani  9
Affiliations

Comparison of gastric juice soluble triggering receptor expressed on myeloid cells and C-reactive protein for detection of Helicobacter pylori infection

Ahmad Piroozmand et al. Electron Physician. .

Abstract

Background and aim: Triggering receptor expressed on myeloid cells (TREM-1) is a receptor on phagocytes that is triggered by infectious agents. The soluble form of it (sTREM-1) can be elevated in gastric juice by Helicobacter pylori (H. pylori) infection of gastric mucosa. The aim of this study was to compare the diagnostic values of sTREM-1 and C-reactive protein (CRP) for detection of H. pylori infection in gastric mucosa.

Methods: In this diagnostic accuracy study on cases who underwent endoscopy from March 2015 to July 2016 in Shahid Beheshti Hospital, Kashan, Iran, gastric juice sTREM-1 and CRP concentrations were measured by enzyme-linked immunosorbent assays (ELISA) and their diagnostic values were compared to detect H. pylori infection. Gold standard test was histopathology. Data were entered into SPSS software version 16. Statistical analysis was made by Kolmogorov-Smirnov, Chi-square, Independent-samples t-test, Kruskal-Wallis, Mann-Whitney U, Pearson product-moment correlation, Receiver operating characteristic curve (ROC), Brier score, Nagelkerke R square and scaled reliability test.

Results: Of a total of 160 cases, 81 (50.6%) were H. pylori-positive based on pathology. The level of sTREM-1 in H. pylori-positive patients was significantly higher than H. pylori-negative patients (p=0.000), but no significant difference between CRP concentrations was shown between groups (p=0.7). Sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and accuracy of sTREM-1 were 82%, 75%, 3.3, 0.25, 78% and for CRP were 62%, 40%, 1.02, 0.98, 51% respectively for diagnosis of H. pylori infection. True positive and negative rates were 66 (81.5%) and 59 (74.7%) for sTREM-1 and 50 (61.7%) and 31 (39.2%) for CRP. The levels of sTREM-1 and CRP were not significantly different between endoscopic finding groups (p=0.97, p=0.2 respectively).

Conclusion: Despite CRP, sTREM-1 was a relatively acceptable indicator of H. pylori infection of gastric mucosa.

Keywords: CRP; Duodenal ulcer; Gastric ulcer; Gastritis; Helicobacter pylori; sTREM-1.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: There is no conflict of interest to be declared.

Figures

Figure 1
Figure 1
Receiver operating characteristic curve (ROC) for soluble triggering receptor expressed on myeloid cells (sTREM-1) and C-reactive protein (CRP).
Figure 2
Figure 2
Calibration plot for soluble triggering receptor expressed on myeloid cells (sTREM-1) concentration (pg/ml) according to optic density (OD).
Figure 3
Figure 3
Calibration plot for C-reactive protein (CRP) concentration (ng/ml) according to optic density (OD).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Padol S, Yuan Y, Thabane M, Padol IT, Hunt RH. The effect of CYP2C19 polymorphisms on H. pylori eradication rate in dual and triple first-line PPI therapies: a meta-analysis. Am J Gastroenterol. 2006;101(7):1467–75. doi: 10.1111/j.1572-0241.2006.00717.x. - DOI - PubMed
    1. Calam J, Baron JH. ABC of the upper gastrointestinal tract: Pathophysiology of duodenal and gastric ulcer and gastric cancer. BMJ. 2001;323(7319):980–2. - PMC - PubMed
    1. Vakil N. Helicobacter pylori treatment: a practical approach. Am J Gastroenterol. 2006;101(3):497–9. doi: 10.1111/j.1572-0241.2006.00454.x. - DOI - PubMed
    1. Eckmann L. Sensor molecules in intestinal innate immunity against bacterial infections. Curr Opin Gastroenterol. 2006;22(2):95–101. doi: 10.1097/01.mog.0000208458.38772.2a. - DOI - PMC - PubMed
    1. Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000;164(10):4991–5. - PubMed

LinkOut - more resources