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Review
. 2017 Winter;6(4):118-124.

Prevalence of Helicobacter pylori Infection in Patients with Central Serous Chorioretinopathy: A Review

Masood Bagheri  1   2 , Zahra Rashe  3 , Mohammad Hosein Ahoor  2 , Mohammad Hosein Somi  1
Affiliations
Review

Prevalence of Helicobacter pylori Infection in Patients with Central Serous Chorioretinopathy: A Review

Masood Bagheri et al. Med Hypothesis Discov Innov Ophthalmol. 2017 Winter.

Abstract

Helicobacter pylori is a prevalent cause of gastrointestinal infections. Recently, several studies have shown a relationship between H. pylori infection and a variety of extradigestive manifestations. The aim of this study was to review the literature regarding the prevalence of this infection in cases of central serous chorioretinopathy (CSR). We reviewed the EMBASE, Cochrane Library, and Google Scholar search engines; hand-searched many journals; and searched the cited references in published articles for relevant studies. We assessed 81 studies for eligibility. Finally, nine articles that met the inclusion criteria were included. The relationship between H. pylori infection (as the etiologic factor) and chorioretinal involvement was assessed by the effect size with 95% confidence interval (CI). Both fixed- and random-effects models showed that the prevalence of H. pylori infection in patients with CSR was significantly higher than in the control group (2.5-fold and 2.7-fold higher, respectively; P < 0.01). The results were not significantly different between the two models. Treatment of H. pylori infection should be considered in patients with CSR. However, additional randomized controlled clinical trials are required to determine the possible role of H. pylori eradication in the prognosis and treatment of patients with CSR.

Keywords: Central Serous Chorioretinopathy; Gastrointestinal Infections; Helicobacter pylori; Prevalence; Systematic Review.

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Conflict of interest statement

This study was approved by the review board ethics committee of the training hospital and Tabriz University of Medical Sciences, Tabriz, Iran. No funding or sponsorship was received for this study. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.

Figures

Figure 1
Figure 1
This figure shows the methodology of the study, in a stepwise fashion.
Figure 2
Figure 2
Prevalence of Helicobacter Pylori Infection in Central Serous Chorioretinopathy (CSR) Group versus Control Group based on Random-Effects Model (up) and Fixed-Effects Model (down).
Figure 3
Figure 3
Funnel Plot of Standard Error against Log Odds Ratio.
See this image and copyright information in PMC

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References

    1. Hosseini H, Ghaffariyeh A, Nikandish R. Noxious compounds in exhaled air, a potential cause for ocular manifestations of H pylori gastrointestinal infection. Med Hypotheses. 2007;68(1):91–3. doi: 10.1016/j.mehy.2006.06.029 pmid: 16919889. - PubMed
    1. Mauget-Faysse M, Kodjikian L, Quaranta M, Ben Ezra D, Trepsat C, Mion F, et al. [Helicobacter pylori in central serous chorioretinopathy and diffuse retinal epitheliopathy Results of the first prospective pilot study] J Fr Ophtalmol. 2002;25(10):1021–5. pmid: 12527825. - PubMed
    1. Sherman PM, Lin FY. Extradigestive manifestation of Helicobacter pylori infection in children and adolescents. Can J Gastroenterol. 2005;19(7):421–4. doi: 10.1155/2005/971974 pmid: 16010304. - PubMed
    1. Zbinden R doi: 10.1007/s15010-005-7205-3 pmid: 15827869. Expanding the spectrum of Helicobacter pylori-associated diseases. Infection. 2005;33(2):49. - PubMed
    1. Sacca SC, Vagge A, Pulliero A, Izzotti A. Helicobacter pylori infection and eye diseases: a systematic review. Medicine (Baltimore) 2014;93(28) doi: 10.1097/MD.0000000000000216 pmid: 25526440. - PMC - PubMed

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