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. 2018 Jan 24;5(3):376-381.
doi: 10.1002/acn3.521. eCollection 2018 Mar.

Clinicopathological and 123I-FP-CIT SPECT correlations in patients with dementia

Youngsin Jung  1 , Lennon G Jordan 3rd  2 , Val J Lowe  2 , Kejal Kantarci  2 , Joseph E Parisi  1   3 , Dennis W Dickson  4 , Melissa E Murray  4 , Ross R Reichard  3 , Tanis J Ferman  5 , David T Jones  1 , Jonathan Graff-Radford  1 , Rodolfo Savica  1 , Mary M Machulda  6 , Julie A Fields  6 , Laura A Allen  1 , Daniel A Drubach  1 , Erik K St Louis  1   7 , Michael H Silber  1   7 , Clifford R Jack Jr  2 , David S Knopman  1 , Ronald C Petersen  1 , Bradley F Boeve  1   7
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Clinicopathological and 123I-FP-CIT SPECT correlations in patients with dementia

Youngsin Jung et al. Ann Clin Transl Neurol. .

Abstract

The relationship between clinicopathologic diagnosis and 123I-FP-CIT SPECT in 18 patients with dementia (12 with Lewy body disease) from one center in the United States was assessed. The sensitivity and specificity of abnormal 123I-FP-CIT SPECT with reduced striatal uptake on visual inspection for predicting Lewy body disease were 91.7% and 83.3%, respectively. The mean calculated putamen to occipital ratio (mPOR) based on regions of interest was significantly reduced in Lewy body disease compared to non-Lewy body disease cases (P = 0.002). In this study, abnormal 123I-FP-CIT SPECT was strongly associated with underlying Lewy body disease pathology, supporting the utility of 123I-FP-CIT SPECT in the clinical diagnosis of dementia with Lewy bodies.

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Figures

Figure 1
Figure 1
123I‐FP‐CIT SPECT demonstrates reduced striatal uptake in LBD cases compared to non‐LBD cases. Representative images are shown. AD, Alzheimer's disease; ADem, Alzheimer's disease dementia; c, clinical diagnosis; CBS, corticobasal syndrome; DLB, dementia with Lewy bodies; FTLD, frontotemporal lobar degeneration; LBD, Lewy body disease; mPOR, mean putamen to occipital ratio; p, pathologic diagnosis; PPA, primary progressive aphasia
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