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Comparative Study
. 2018 Sep;37(9):943-948.
doi: 10.1097/INF.0000000000001988.

Rotavirus Vaccines and Health Care Utilization for Diarrhea in US Children, 2001 to 2015

Halle B Getachew  1 , Rebecca M Dahl  2 , Benjamin A Lopman  1   3 , Umesh D Parashar  1
Affiliations
Comparative Study

Rotavirus Vaccines and Health Care Utilization for Diarrhea in US Children, 2001 to 2015

Halle B Getachew et al. Pediatr Infect Dis J. 2018 Sep.

Abstract

Background: Rotavirus vaccination was introduced in the United States in 2006. Our objectives were to examine reductions in diarrhea-associated health care utilization after rotavirus vaccine implementation and to assess direct vaccine effectiveness (VE) in US children.

Methods: Retrospective cohort study using claims data of US children under 5 years of age. We compared rates of diarrhea-associated health care utilization in prevaccine versus postvaccine introduction years. We also examined VE and duration of protection.

Results: Compared with the average rate of rotavirus-coded hospitalizations in the prevaccine years, overall vaccine rates were reduced by 75% in 2007 to 2008, 60% in 2008 to 2009, 94% in 2009 to 2010, 80% in 2010 to 2011, 97% in 2011 to 2012, 88% in 2012 to 2013, 98% in 2013 to 2014 and 92% in 2014 to 2015. RotaTeq-adjusted VE was 88% against rotavirus-coded hospitalization among 3-11 months of age, 88% in 12-23 months of age, 87% in 24-35 months of age, 87% in 36-47 months of age and 87% in 48-59 months of age. Rotarix-adjusted VE was 87% against rotavirus-coded hospitalization among 3-11 months of age, 86% in 12-23 months of age and 86% in 24-35 months of age.

Conclusion: Implementation of rotavirus vaccines has substantially reduced diarrhea-associated health care utilization in US children under 5 years of age. Both vaccines provided good and enduring protection through the fourth year of life against rotavirus hospitalizations.

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Figures

FIGURE 1.
FIGURE 1.
Diarrhea-associated health care utilization rates among children, 5 years of age, 2001 to 2015.
See this image and copyright information in PMC

References

    1. Parashar UD, Gibson CJ, Bresee JS, et al. Rotavirus and severe childhood diarrhea. Emerg Infect Dis. 2006;12:304–306. - PMC - PubMed
    1. Cortese MM, Parashar UD; Centers for Disease Control and Prevention (CDC). Prevention of rotavirus gastroenteritis among infants and children: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2009;58:1–25. - PubMed
    1. Prevention of rotavirus disease: updated guidelines for use of rotavirus vaccine. Pediatrics. 2009;123:1412–1420. - PubMed
    1. Cortes JE, Curns AT, Tate JE, et al. Rotavirus vaccine and health care utilization for diarrhea in U.S. children. N Engl J Med. 2011;365:1108–1117. - PubMed
    1. Leshem E, Moritz RE, Curns AT, et al. Rotavirus vaccines and health care utilization for diarrhea in the United States (2007–2011). Pediatrics. 2014;134:15–23. - PMC - PubMed

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