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Clinical Trial
. 1987 Jul;17(1):32-9.
doi: 10.1016/s0190-9622(87)70167-4.

Controlled double-blind trial of fibrinolysin-desoxyribonuclease (Elase) solution in patients with chronic leg ulcers who are treated before autologous skin grafting

W Westerhof, F C Jansen, F S de Wit, R H Cormane
Clinical Trial

Controlled double-blind trial of fibrinolysin-desoxyribonuclease (Elase) solution in patients with chronic leg ulcers who are treated before autologous skin grafting

W Westerhof et al. J Am Acad Dermatol. 1987 Jul.

Abstract

A controlled, randomized, double-blind trial was performed in 34 hospitalized patients with chronic leg ulcers: 37 ulcerous legs were treated with Elase solution or with saline (placebo) solution. Elase was statistically significantly better in effect on debridement (p less than 0.05) and on enhancing of granulation (p less than 0.05) than saline in patients with chronic venous stasis ulcers. In patients with complex ulcers no statistically significant difference between the two treatments was seen.

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