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Comparative Study
. 1987 Jun;234(5):289-91.
doi: 10.1007/BF00314282.

CSF beta-endorphin and leu-enkephalin levels in the acute and chronic stages of cerebral infarction

M Kobari, N Ishihara, K Yunoki
Comparative Study

CSF beta-endorphin and leu-enkephalin levels in the acute and chronic stages of cerebral infarction

M Kobari et al. J Neurol. 1987 Jun.

Abstract

To investigate the role of endogenous opioid peptides in the pathophysiology of cerebral ischaemia, the CSF levels of immunoreactive beta-endorphin and leu-enkephalin in 16 patients with cerebral infarction were measured. Both the CSF beta-endorphin and leu-enkephalin levels in the acute stage of cerebral infarction were significantly higher than the values in the chronic stage. The CSF concentrations of the two peptides revealed a positive correlation in the acute but not the chronic stage. The increased endogenous opioid peptides in the CSF in the acute stage may modify the evolution of cerebral infarction.

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