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. 2018 Mar;9(1):15-23.
doi: 10.1007/s13193-017-0658-x. Epub 2017 May 11.

Operable Oral Tongue Squamous Cell Cancer: 15 Years Experience at a Tertiary Care Center in North India

Nootan Kumar Shukla  1 , S V Suryanarayana Deo  1 , Pankaj Kumar Garg  1   2 , N M L Manjunath  1 , Suman Bhaskar  3 , V Sreenivas  4
Affiliations

Operable Oral Tongue Squamous Cell Cancer: 15 Years Experience at a Tertiary Care Center in North India

Nootan Kumar Shukla et al. Indian J Surg Oncol. 2018 Mar.

Abstract

The aim of the present study was to provide insight into various demographic, clinical, and management profile of Indian patients with oral tongue squamous cell cancer (OTSCC). All the OTSCC patients who had undergone surgical treatment during 1995 to 2010 at a tertiary care center in North India were considered for the present study. The details of the patients were retrieved from a prospectively maintained computerized database. A total of 124 patients were included in the present study. Mean age of the patients was 50.4 ± 12.0 years. Lateral border of the tongue was the most common sub-site involved in 110 (88.7%) patients. Neck nodes were clinically palpable in 56.4% patients. Hemiglossectomy and anterior partial glossectomy were common surgical procedure undertaken in 57.2 and 25.8% patients. Negative resection margin was achieved in 97.5% patients. Pathological neck metastasis was seen in 40.3% patients. Occult neck metastasis was present in 25.9% patients among clinical N0 neck. At a mean follow-up of 29.8 months (SD 3.1), 20.1% developed disease relapse and 4.0% patients developed second primaries. Kaplan-Meier analysis estimated a 5-year disease-free survival of 81.5% and a 5 years overall survival of 78.6%. Cox proportional regression analysis predicted tumor size and number of positive nodes to be independent predictive variables for disease recurrence. Quality controlled surgery, coupled with adjuvant treatment when required, provides a safe and effective treatment of OTSCC with a good disease-free survival and loco-regional control.

Keywords: Chemotherapy; Glossectomy; Oral neoplasms; Radiotherapy; Survival analysis; Tongue neoplasms.

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Conflict of interest statement

Compliance with Ethical StandardsNone to declare.

Figures

Fig. 1
Fig. 1
Kaplan-Meier curve showing a disease-free survival and b overall survival
Fig. 2
Fig. 2
Survival curves for various T stages with respect to disease-free survival (Log rank test). Number of patients in various T stages: T1–42, T2–59, T3–11, T4–12
Fig. 3
Fig. 3
Survival curves for node status (N0 vs. N1 vs. N2) with respect to disease-free survival (Log rank test)
Fig. 4
Fig. 4
Survival curves for final TNM stages with respect to disease-free survival (Log rank test)
See this image and copyright information in PMC

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