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. 2018 Mar 7:11:1293-1303.
doi: 10.2147/OTT.S154227. eCollection 2018.

The clinicopathological and prognostic value of HSP27 in hepatocellular carcinoma: a systematic review and meta-analysis

Chaojie Liang #  1 , Yingchen Xu #  1 , Hua Ge  1 , Guangming Li  1 , Jixiang Wu  1
Affiliations

The clinicopathological and prognostic value of HSP27 in hepatocellular carcinoma: a systematic review and meta-analysis

Chaojie Liang et al. Onco Targets Ther. .

Abstract

Background: In the recent past, there is increasing evidence demonstrating that HSP27 plays a key role in tumor progression. However, the relationship between HSP27 expression and the clinicopathological features of hepatocellular carcinoma (HCC), as well as its prognostic value in HCC patients remain controversial. Accordingly, we conducted a meta-analysis to assess the correlation between HSP27 expression and HCC, and determine the prognostic value of HSP27 in HCC.

Methods: The data included clinicopathological features and survival information extracted from the published literature in the databases PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, and Wan Fang. The pooled odds ratios and hazard ratios with 95% CIs were calculated using Forest plot analysis.

Results: The meta-analysis results indicated that the positive HSP27 expression was significantly correlated with HCC incidence, tumor differentiation, and α-fetoprotein level in patients with HCC. However, the expression of HSP27 was not associated with metastasis, hepatitis B virus surface antigen, gender, tumor size, TNM stage, and vascular invasion. Additionally, HSP27 expression indicated a poor overall survival rate, but it was not related to disease-free survival rate.

Conclusion: This meta-analysis revealed that HSP27 may play a key role in the development of HCC and could be a reliable biomarker for the prognosis of patients with HCC. However, additional high-quality research is needed to support the results.

Keywords: HCC; heat shock protein 27; meta-analysis.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of study selection process.
Figure 2
Figure 2
Forest plot and funnel plots of studies evaluating the relationship between HSP27 expression and clinicopathological features. Notes: (A) Expression; (B) gender; (C) AFP level. Weights are from random effects analysis. Abbreviations: AFP, α-fetoprotein; OR, odds ratio.
Figure 3
Figure 3
Forest plot and funnel plots of studies evaluating the relationship between HSP27 expression and clinicopathological features. Notes: (A) HBsAg; (B) tumor size; (C) metastasis. Weights are from random effects analysis. Abbreviation: OR, odds ratio.
Figure 4
Figure 4
Forest plot and funnel plots of studies evaluating the relationship between HSP27 expression and clinicopathological features. Notes: (A) Vascular invasion; (B) tumor differentiation; (C) TNM stage. Weights are from random effects analysis. Abbreviation: OR, odds ratio.
Figure 5
Figure 5
Forest plot and funnel plots of studies evaluating the relationship between HSP27 expression and prognosis of HCC patients. Notes: (A) Overall survival; (B) disease-free survival. Weights are from random effects analysis. Abbreviations: HCC, hepatocellular carcinoma; HR, hazard ratio.
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