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. 2018 Mar 8:11:109-113.
doi: 10.2147/CCID.S156324. eCollection 2018.

In vivo validation of the multicomponent powder (Vitachelox®) against the deposition of polluting ions

Luca Giacomelli  1 , Stefano Togni  2 , Martino Meneghin  2 , Roberto Eggenhöffner  1 , Giada Maramaldi  2
Affiliations

In vivo validation of the multicomponent powder (Vitachelox®) against the deposition of polluting ions

Luca Giacomelli et al. Clin Cosmet Investig Dermatol. .

Abstract

Purpose: The purpose of this in vivo study is to evaluate the acute clinical application of a multicomponent powder (Vitachelox®), including three naturally occurring standardized extracts rich in polyphenols (grape seed extract, green tea extract, oak wood/bark extract), on healthy volunteers by measuring prevention of any metal deposition within the stratum corneum (SC) following a 6-h exposure period in a polluted environment.

Patients and methods: In this in vivo study, we evaluated the skin protective activity of the multicomponent powder formulated in a base emulsion compared to a relevant placebo cream. Using the tape stripping method, SC samples of face skin obtained from 30 healthy volunteers were compared following a 6-h exposure in a polluted area.

Results: No statistically significant variations on the amount of heavy metals were found in the samples of SC cells obtained from the hemi-faces treated with the multicomponent powder, with respect to baseline. On the contrary, a significantly higher concentration of heavy metals was found in the cells samples obtained from the hemi-faces treated with the placebo cream. In particular, an increased concentration of heavy metals superior to 100% were found for iron and zinc (+130.2% and +142.6%, respectively; p<0.001).

Conclusion: This in vivo study validates and extends previous in vitro findings, indicating that the multicomponent powder allows the prevention of any metal deposition within the SC following exposure in a polluted environment. Our results suggest that the test product could play an effective role in counteracting skin damages induced by air pollution.

Keywords: air pollution; antipollution; grape seed extract; green tea extract; heavy metals; oak wood extract; oxidative stress; polyphenols; stratum corneum.

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Conflict of interest statement

Disclosure ST, MM, and GM are employees of Indena S.p.A. LG is a consultant of Indena S.p.A. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Variation (%) in the concentration of heavy metals in SC cells samples. *p<0.001. Abbreviations: Cr, chrome; Fe, iron; Ni, nickel; SC, stratum corneum; Zn, zinc.
See this image and copyright information in PMC

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