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. 2017 Oct-Dec;6(4):750-754.
doi: 10.4103/jfmpc.jfmpc_158_17.

Relationship between serum ferritin level and transient elastography findings among patients with nonalcoholic fatty liver disease

Seyed Saeed Seyedian  1   2 , Eskandar Hajiani  1   2 , Seyed Jalal Hashemi  1   2 , Abdolrahim Masjedizadeh  1   2 , Ali Akbar Shayesteh  1   2 , Pezhman Alavinejad  1   2 , Ahmad Hormati  3 , Ali Javaherforoushzadeh  1   2 , Mehdi Khabazkhoob  4
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Relationship between serum ferritin level and transient elastography findings among patients with nonalcoholic fatty liver disease

Seyed Saeed Seyedian et al. J Family Med Prim Care. 2017 Oct-Dec.

Abstract

Introduction: Nonalcoholic fatty liver disease (NAFLD) is raising prevalence among children, and adolescence population in developed and developing countries as a major public health concern. The present study aims to determine the relationship between serum ferritin level and transient elastography findings in patients suffering from NAFLD.

Materials and methods: The demographic and biochemical profile of included individuals such as body mass index, age, level of serum transaminases, fasting blood sugar, lipid profile, and serum ferritin level were determined and a transient elastography was performed for all of them.

Results: The mean serum ferritin level among men with mild and advanced liver stiffness was 154 ± 97 and 244 ± 214, respectively (P < 0.001), which showed a meaningful relationship. These figures among female patients with mild and advanced liver stiffness included 79 ± 91 and 161 ± 103, respectively (P = 0.003) and again revealed a significant relationship. The cutoff values of ferritin with 90% accuracy for differentiation of mild from advanced liver stiffness among male and female patients were determined as 255 ng/ml and 135 ng/ml, respectively. These cutoff values for ruling out of advanced liver stiffness with 90% accuracy among both sexes were 72.5 ng/ml and 65.5 ng/ml, respectively.

Conclusion: The finding of this study revealed a significant relationship between serum ferritin level and liver stiffness among NAFLD patients, and if these results repeated in further investigations, it could be advisable to measure serum ferritin level for predicting possibility of advanced liver fibrosis.

Keywords: Ferritin; nonalcoholic fatty liver disease; transient elastography.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Relationship of serum ferritin level with liver stiffness in male and female based on receiver operating characteristic curve
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