A rare melanoma feature with primary ovarian origin: a case report and the literature review

Abstract

Primary ovarian melanoma arising on a mature ovarian cystic teratoma is extremely rare. As best of our knowledge, to date, 49 cases have been reported in literature. Few information was reported about best management and therapy. We present a case occurred in a 69-year-old woman, without symptoms, who come to our unit for stress incontinence. A pelvic mass was detected and, after imaging evaluation, surgery was performed. The diagnosis was ovarian melanoma arose on a mature teratoma. No other adjuvant treatment was proposed after surgery. She died 9 months after the first diagnosis. Primary ovarian melanoma is a definite entity associated with a variable natural history and poor prognosis. Differential diagnosis is a challenge for the pathologist, because it must be differentiated by metastatic melanoma. The corner stone treatment of this disease is surgery; however, chemotherapy, immunotherapy, and target therapy seem to have a role.

Keywords: Melanoma; Ovarian cancer; Teratoma.

Fig. 1

(A) cyst wall (original magnification ×10). (B) hematoxylin-eosin (original magnification ×40). (C) hematoxylin-eosin with brown pigment (original magnification ×40). (D) Immunostain for Melan A shows a diffuse, intensively cytoplasmic positive reaction.