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Review
. 2018 Apr;78(5):601-606.
doi: 10.1007/s40265-018-0896-4.

Bictegravir: First Global Approval

Anthony Markham  1
Affiliations
Review

Bictegravir: First Global Approval

Anthony Markham. Drugs. 2018 Apr.

Abstract

Gilead Sciences has developed a single tablet anti-HIV-1 medication (Biktarvy®) combining the novel integrase strand transfer inhibitor (INSTI) bictegravir with the nucleos(t)ide reverse transcriptase inhibitors (NRTIs) emtricitabine and tenofovir alafenamide. This fixed dose combination has demonstrated efficacy as treatment for both anti-retroviral naïve and virologically suppressed HIV-1 infection in patients switching therapy, and was recently approved in the USA. This article summarizes the milestones in the development of bictegravir leading to this first approval of bictegravir/emtricitabine/tenofovir alafenamide as treatment for HIV-1 infection.

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