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Observational Study
. 2018 Feb 20;190(7):E184-E190.
doi: 10.1503/cmaj.161403.

Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study

Yibo Li  1 , Jenelle L Pederson  1 , Thomas A Churchill  1 , Adrian S Wagg  1 , Jayna M Holroyd-Leduc  1 , Kannayiram Alagiakrishnan  1 , Raj S Padwal  1 , Rachel G Khadaroo  2
Affiliations
Observational Study

Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study

Yibo Li et al. CMAJ. .

Abstract

Background: Frailty is a state of vulnerability to diverse stressors. We assessed the impact of frailty on outcomes after discharge in older surgical patients.

Methods: We prospectively followed patients 65 years of age or older who underwent emergency abdominal surgery at either of 2 tertiary care centres and who needed assistance with fewer than 3 activities of daily living. Preadmission frailty was defined according to the Canadian Study of Health and Aging Clinical Frailty Scale as "well" (score 1 or 2), "vulnerable" (score 3 or 4) or "frail" (score 5 or 6). We assessed composite end points of 30-day and 6-month all-cause readmission or death by multivariable logistic regression.

Results: Of 308 patients (median age 75 [range 65-94] yr, median Clinical Frailty Score 3 [range 1-6]), 168 (54.5%) were classified as vulnerable and 68 (22.1%) as frail. Ten (4.2%) of those classified as vulnerable or frail received a geriatric consultation. At 30 days after discharge, the proportions of patients who were readmitted or had died were greater among vulnerable patients (n = 27 [16.1%]; adjusted odds ratio [OR] 4.60, 95% confidence interval [CI] 1.29-16.45) and frail patients (n = 12 [17.6%]; adjusted OR 4.51, 95% CI 1.13-17.94) than among patients who were well (n = 3 [4.2%]). By 6 months, the degree of frailty independently and dose-dependently predicted readmission or death: 56 (33.3%) of the vulnerable patients (adjusted OR 2.15, 95% CI 1.01-4.55) and 37 (54.4%) of the frail patients (adjusted OR 3.27, 95% CI 1.32-8.12) were readmitted or had died, compared with 11 (15.3%) of the patients who were well.

Interpretation: Vulnerability and frailty were prevalent in older patients undergoing surgery and unlikely to trigger specialized geriatric assessment, yet remained independently associated with greater risk of readmission for as long as 6 months after discharge. Therefore, the degree of frailty has important prognostic value for readmission.

Trial registration for primary study: ClinicalTrials.gov, no. NCT02233153.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1:
Figure 1:
Selection of study patients. ADLs = activities of daily living.
Figure 2:
Figure 2:
Relation between preadmission frailty and outcome after discharge.
See this image and copyright information in PMC

Comment in

References

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