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Review
. 2018 May;39(5):845-857.
doi: 10.1038/aps.2017.182. Epub 2018 Mar 22.

Organ preservation: from the past to the future

Lei Jing  1   2 , Leeann Yao  2 , Michael Zhao  2 , Li-Ping Peng  1 , Mingyao Liu  2
Affiliations
Review

Organ preservation: from the past to the future

Lei Jing et al. Acta Pharmacol Sin. 2018 May.

Abstract

Organ transplantation is the most effective therapy for patients with end-stage disease. Preservation solutions and techniques are crucial for donor organ quality, which is directly related to morbidity and survival after transplantation. Currently, static cold storage (SCS) is the standard method for organ preservation. However, preservation time with SCS is limited as prolonged cold storage increases the risk of early graft dysfunction that contributes to chronic complications. Furthermore, the growing demand for the use of marginal donor organs requires methods for organ assessment and repair. Machine perfusion has resurfaced and dominates current research on organ preservation. It is credited to its dynamic nature and physiological-like environment. The development of more sophisticated machine perfusion techniques and better perfusates may lead to organ repair/reconditioning. This review describes the history of organ preservation, summarizes the progresses that has been made to date, and discusses future directions for organ preservation.

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Figures

Figure 1
Figure 1
Biological processes induced during ischemia-reperfusion that may lead to primary graft dysfunction.
Figure 2
Figure 2
Metabolic rate reduces with a decrease in temperature in humans. (SCS=static cold storage, HMP=hypothermic machine perfusion, COR=controlled oxygenated rewarming, SNMP=subnormothermic machine perfusion, and NMP=normothermic machine perfusion).
Figure 3
Figure 3
The advantage of the potential use of normothermic machine perfusion.
See this image and copyright information in PMC

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