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. 2018 Mar 22;13(3):e0194775.
doi: 10.1371/journal.pone.0194775. eCollection 2018.

Patterns of sensitization to inhalant and food allergens among pediatric patients from the Moscow region (Russian Federation)

Sergei Voloshin  1 , Olga Smoldovskaya  1 , Guzel Feyzkhanova  1 , Alla Arefieva  1 , Lyudmila Pavlushkina  2 , Tatiana Filatova  2 , Veronika Butvilovskaya  1 , Marina Filippova  1 , Yuri Lysov  1 , Sergey Shcherbo  2 , Alexander Makarov  1 , Alla Rubina  1 , Alexander Zasedatelev  1
Affiliations

Patterns of sensitization to inhalant and food allergens among pediatric patients from the Moscow region (Russian Federation)

Sergei Voloshin et al. PLoS One. .

Abstract

The immunological profiles of human specific IgE (sIgE) and specific IgG4 (sIgG4) vary by genetic predisposition, living conditions in different geographical locations and patient's age. The aim of our study was to analyze sIgE and sIgG4 patterns and their age-dependent changes in patients from the Moscow region. For identifying sIgE and sIgG4 profiles the blood samples from 513 patients aged 6 months to 17 years who were showing symptoms of allergic diseases were analyzed using microarrays containing 31 allergens. The highest sIgE prevalence was observed for birch pollen (32%) among pollen allergens, cat dander (24%) among indoor allergens, and egg whites (21%) among food allergens. The most common sIgG4 response was developed toward egg whites (80% of patients). Age-related elevation was identified for patients with increased sIgE to pollen allergens and indoor allergens (cat or dog dander and house dust mites). For each allergen, the proportion of cases with significant levels of sIgG4 appeared to increase with patients' age. The data on allergen-specific sIgE and sIgG4 prevalence show both general trends and some local special aspects that are indicative for the Moscow region. This information should be useful in terms of epidemiology of allergic diseases.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The proportion of pediatric patients with allergic symptoms accompanied by allergen-specific IgE or IgG4 response.
Immunoglobulin response was considered to be present in cases of increased concentration of sIgE (≥0.35 IU/ml) or a significant level of sIgG4 (≥110 ng/ml) to allergens.
Fig 2
Fig 2. Comparison of sensitization rates from different studies.
The proportion of samples with sIgE-increased concentration to each of the 31 allergens for children aged 0 to 17 years according to our data in comparison with the data of other studies conducted in the Netherlands [19] and Taiwan [20].
Fig 3
Fig 3. Age-dependent changes in the proportion of patients with increased concentrations of sIgE.
Fig 4
Fig 4. Age-dependent changes in the proportion of patients with significant concentrations of sIgG4.
See this image and copyright information in PMC

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