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. 2018 Apr 19;36(17):2233-2236.
doi: 10.1016/j.vaccine.2018.03.008. Epub 2018 Mar 19.

The future control of rotavirus disease: Can live oral vaccines alone solve the rotavirus problem?

Roger I Glass  1 , Baoming Jiang  2 , Umesh Parashar  2
Affiliations

The future control of rotavirus disease: Can live oral vaccines alone solve the rotavirus problem?

Roger I Glass et al. Vaccine. .

Abstract

Live oral rotavirus (RV) vaccines used worldwide are most effective in reducing diarrheal hospitalizations from RV in high income countries and least effective in low income countries where RV remains a prime cause of death in children. Research has failed to fully explain the reason for this difference of efficacy for RV vaccines, an observation made with other live oral vaccines for polio, cholera and typhoid fever. Use of parenteral vaccines have been successful in overcoming this problem for both polio and typhoid and parenteral RV vaccines are now in development. This approach should be pursued for rotavirus vaccine as well because in low income countries where oral RV vaccines have been introduced and are only partially effective, RV remains the most common cause of diarrhea in children under 5 years. The ultimate control of RV diarrheal will likely require both oral and parenteral vaccines.

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Conflict of interest statement

The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention. CDC holds the patents for CDC strains and inactivation methods developed by Drs. Jiang and Glass. No other conflicts to report.

Figures

Fig. 1.
Fig. 1.
Effectiveness of oral rotavirus vaccines by a country’s per capita GDP.
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