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Comment
. 2018 Apr 3;37(7):e99206.
doi: 10.15252/embj.201899206. Epub 2018 Mar 22.

Paligenosis: prepare to regenerate!

Hendrik A Messal  1 , Catherine A Cremona  1 , Linxiang Lan  1 , Axel Behrens  1   2
Affiliations
Comment

Paligenosis: prepare to regenerate!

Hendrik A Messal et al. EMBO J. .

Abstract

Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy‐ and mTORC1‐dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program.

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Figures

Figure 1
Figure 1. The paligenosis program
Upon damaging insult, chief cells in the stomach and pancreatic acinar cells decrease metabolic activity whilst temporarily activating lysosomes and autophagic machinery. At later stages, cells induce expression of metaplasia and wound‐healing associated genes including Sox9, Clu and Cd44v, reactivate metabolism and enter the cell cycle. SPEM (spasmolytic polypeptide‐expressing metaplasia) in the stomach and ADM (acinar‐to‐ductal metaplasia) in the pancreas mark the crossroads between tissue regeneration and transformation into precancerous lesions.
See this image and copyright information in PMC

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