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Meta-Analysis
. 2018 Mar 23:23:197-206.
doi: 10.12659/AOT.908774.

Normothermic Machine Perfusion versus Cold Storage of Liver in Pig Model: A Meta-Analysis

Shiqi Bian  1 , Zhijun Zhu  1   2   3 , Liying Sun  1   4   3 , Lin Wei  1   2 , Wei Qu  1   2 , Zhigui Zeng  1   2 , Ying Liu  1   2
Affiliations
Meta-Analysis

Normothermic Machine Perfusion versus Cold Storage of Liver in Pig Model: A Meta-Analysis

Shiqi Bian et al. Ann Transplant. .

Abstract

BACKGROUND Normothermic machine perfusion (NMP) is a novel strategy used for organ preservation. We aimed to determine the overall efficacy of NMP for liver preservation versus traditional static cold storage (CS). MATERIAL AND METHODS We performed a meta-analysis of the literature to evaluate the efficacy of NMP in experimental pig models of liver preservation. We use the standardized mean difference and 95% confidence intervals (CI) to calculate statistics and used the random effects model for the combined analysis of the results. RESULTS A total of 16 studies from 12 published articles were included. The combined results showed that NMP significantly decreased alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hyaluronic acid levels in serum or perfusate, significantly increased bile production, and had a similar 5-7-days survival rate after liver transplantation compared with the CS group. CONCLUSIONS NMP provides superior graft preservation compared with CS in the pig model.

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Conflict of interest statement

Conflict of interest

None.

Figures

Figure 1
Figure 1
Search strategy for selection of studies.
Figure 2
Figure 2
Effect of NMP vs. CS preservation on ALT level. Results of meta-analysis according to the random effects model.
Figure 3
Figure 3
Effect of NMP vs. CS preservation on AST level. Results of meta-analysis according to the random effects model.
Figure 4
Figure 4
Effect of NMP vs. CS preservation on SEC damage. Results of meta-analysis according to the random effects model.
Figure 5
Figure 5
Effect of NMP vs. CS preservation on liver synthetic function. Results of meta-analysis according to the random effects model.
Figure 6
Figure 6
Effect of NMP vs. CS preservation on survival rate. Results of meta-analysis according to the random effects model.
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