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Review
. 2018 Mar 5:7:F1000 Faculty Rev-263.
doi: 10.12688/f1000research.11148.1. eCollection 2018.

Recent advances in understanding acute respiratory distress syndrome

Peter Wohlrab  1 , Felix Kraft  1 , Verena Tretter  1 , Roman Ullrich  1 , Klaus Markstaller  1 , Klaus Ulrich Klein  1
Affiliations
Review

Recent advances in understanding acute respiratory distress syndrome

Peter Wohlrab et al. F1000Res. .

Abstract

Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse lung injury, which results in increased pulmonary vascular permeability and loss of aerated lung tissue. This causes bilateral opacity consistent with pulmonary edema, hypoxemia, increased venous admixture, and decreased lung compliance such that patients with ARDS need supportive care in the intensive care unit to maintain oxygenation and prevent adverse outcomes. Recently, advances in understanding the underlying pathophysiology of ARDS led to new approaches in managing these patients. In this review, we want to focus on recent scientific evidence in the field of ARDS research and discuss promising new developments in the treatment of this disease.

Keywords: acute respiratory distress syndrome; therapeutic targets; ventilation.

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Conflict of interest statement

Competing interests: None of the authors has to declare any conflict of interest with regard to the present F1000 review. Roman Ullrich received funding from Apeptico GmbH (Vienna, Austria) using funds from grant no. 833159 of the Austrian Research Promotion Agency (FFG) to perform a clinical study investigating AP301 (cited in text PMID: 28750677).No competing interests were disclosed.No competing interests were disclosed.

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