Report from the First EPIICAL (Early-treated Perinatally HIV-infected Individuals: Improving Children's Actual Life with Novel Immunotherapeutic Strategies) General Assembly meeting, 9-11 November 2017, Rome, Italy

P Zangari¹, P Palma¹, N Cotugno¹, P Rojo², A Tagarro², I Pepponi¹, A De Rossi³, L Kuhn⁴, S Pahwa⁵, M Cameron⁶, E Nastouli⁷, S Watters⁸, A G Marceline⁹, L E McCoy¹⁰, D Persaud¹¹, A Violari¹², M Chan¹³, A G Babiker¹³, C Foster¹⁴, J Ananworanich¹⁵, C Giaquinto¹⁶, P Rossi¹

Affiliations

¹ Academic Department of Pediatrics (DPUO), Research Unit in Congenital and Perinatal Infection, Immune and Infectious Diseases Division, Children's Hospital Bambino Gesù (OPBG), Rome, Italy.
² Department of Pediatrics, Hospital 12 de Octubre, Madrid, Spain.
³ Section of Oncology and Immunology, Department of Surgery, Oncology and Gastroenterology-DiSCOG, University of Padova, and Istituto Oncologico Veneto, Padova, Italy.
⁴ Gertrude H Sergievsky Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.
⁵ Department of Microbiology and Immunology, Miami Center for AIDS Research, University of Miami, Miller School of Medicine, Miami, FL, USA.
⁶ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
⁷ Department of Virology, University College London Hospitals, London, UK.
⁸ Infection, Inflammation and Rheumatology Section, University College London Great Ormond Street Institute of Child Health, London, UK.
⁹ Sorbonne University, UPMC University of Paris 6, Service de Virologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
¹⁰ Division of Infection and Immunity, University College London, UK.
¹¹ Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University, School of Medicine, Baltimore, MA, USA.
¹² Perinatal Health Research Unit, University of Witwatersrand, Johannesburg, South Africa.
¹³ MRC Clinical Trials Unit, University College London, UK.
¹⁴ Imperial College Healthcare National Health Service Trust, London, UK.
¹⁵ Henry M Jackson Foundation for the Advancement of Military Medicine, MA, USA.
¹⁶ Department of Women's and Child's Health, Paediatric Infectious Diseases Unit, University of Padova and PENTA Foundation, Padova, Italy.

PMID: 29568555
PMCID: PMC5851186
DOI: 10.1016/S2055-6640(20)30240-5

Editorial

Report from the First EPIICAL (Early-treated Perinatally HIV-infected Individuals: Improving Children's Actual Life with Novel Immunotherapeutic Strategies) General Assembly meeting, 9-11 November 2017, Rome, Italy

P Zangari et al. J Virus Erad. 2018.

. 2018 Jan 1;4(1):51-54.

doi: 10.1016/S2055-6640(20)30240-5.

Authors

Affiliations

¹ Academic Department of Pediatrics (DPUO), Research Unit in Congenital and Perinatal Infection, Immune and Infectious Diseases Division, Children's Hospital Bambino Gesù (OPBG), Rome, Italy.
² Department of Pediatrics, Hospital 12 de Octubre, Madrid, Spain.
³ Section of Oncology and Immunology, Department of Surgery, Oncology and Gastroenterology-DiSCOG, University of Padova, and Istituto Oncologico Veneto, Padova, Italy.
⁴ Gertrude H Sergievsky Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.
⁵ Department of Microbiology and Immunology, Miami Center for AIDS Research, University of Miami, Miller School of Medicine, Miami, FL, USA.
⁶ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
⁷ Department of Virology, University College London Hospitals, London, UK.
⁸ Infection, Inflammation and Rheumatology Section, University College London Great Ormond Street Institute of Child Health, London, UK.
⁹ Sorbonne University, UPMC University of Paris 6, Service de Virologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
¹⁰ Division of Infection and Immunity, University College London, UK.
¹¹ Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University, School of Medicine, Baltimore, MA, USA.
¹² Perinatal Health Research Unit, University of Witwatersrand, Johannesburg, South Africa.
¹³ MRC Clinical Trials Unit, University College London, UK.
¹⁴ Imperial College Healthcare National Health Service Trust, London, UK.
¹⁵ Henry M Jackson Foundation for the Advancement of Military Medicine, MA, USA.
¹⁶ Department of Women's and Child's Health, Paediatric Infectious Diseases Unit, University of Padova and PENTA Foundation, Padova, Italy.

PMID: 29568555
PMCID: PMC5851186
DOI: 10.1016/S2055-6640(20)30240-5

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Figures

**Figure 1.**
The overall goals of the EPIICAL project (above) and the milestones achieved during the first 18 months of activity (below). PoC: proof of concept; NDMT: novel disease modifying therapies

See this image and copyright information in PMC

References

1. Palma P, Foster C, Rojo P et al. . The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children. J Virus Erad 2015; 1: 134– 139. - PMC - PubMed
1. Chan M, Tagarro A, Zangari P et al. . Factors associated with HIV-DNA levels in children starting ART early in infancy. Conference on Retroviruses and Opportunistic Infections. March 2018. Boston, MA, USA.
1. Violari A, Cotton M, Kuhn L et al. . Viral and host characteristics of a child with perinatal HIV-1 following a prolonged period after ART cessation in the CHER trial. International AIDS Society Conference. July 2017. Paris, France. Abstract TUPDB0106LB.
1. Kuhn L, Schramm DB, Shiau S et al. . Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed. AIDS 2015; 29: 1053– 1060. - PMC - PubMed
1. Cotugno N, Morrocchi E, Pepponi I et al. . HIV specific IgM memory B cells dominate in seronegative early-treated children. Conference on Retroviruses and Opportunistic Infections. March 2018. Boston, MA, USA.

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Report from the First EPIICAL (Early-treated Perinatally HIV-infected Individuals: Improving Children's Actual Life with Novel Immunotherapeutic Strategies) General Assembly meeting, 9-11 November 2017, Rome, Italy

Affiliations

Report from the First EPIICAL (Early-treated Perinatally HIV-infected Individuals: Improving Children's Actual Life with Novel Immunotherapeutic Strategies) General Assembly meeting, 9-11 November 2017, Rome, Italy

Authors

Affiliations

Figures

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources