Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 May 13;17(1):451.
doi: 10.4102/sajhivmed.v17i1.451. eCollection 2016.

Recommendations for the management of indeterminate HIV PCR results within South Africa's early infant diagnosis programme

Ahmad Haeri Mazanderani  1   2 , Karl-Günter Technau  3   4 , Nei-Yuan Hsiao  5   6 , Jean Maritz  6   7 , Sergio Carmona  6   8 , Gayle G Sherman  1   4
Affiliations
Review

Recommendations for the management of indeterminate HIV PCR results within South Africa's early infant diagnosis programme

Ahmad Haeri Mazanderani et al. South Afr J HIV Med. .

Abstract

Indeterminate HIV PCR results represent missed diagnostic opportunities within South Africa's early infant diagnosis programme. These results not only delay diagnosis and appropriate management but are also a source of confusion and apprehension amongst clinicians and caregivers. We describe the extent of indeterminate HIV PCR results within South Africa's early infant diagnosis programme and provide recommendations for the management of these cases, both in terms of laboratory practice and the clinical care of the infants.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no financial or personal relationships which may have inappropriately influenced them in writing this article.

Figures

FIGURE 1
FIGURE 1
Scenario A.
FIGURE 2
FIGURE 2
Scenario B.
See this image and copyright information in PMC

References

    1. Newell ML, Coovadia H, Cortina-Borja M, et al. . Mortality of infected and uninfected infants born to HIV infected mothers in Africa: A pooled analysis. Lancet. 2004;364:1236–1243. http://dx.doi.org/10.1016/S0140-6736(04)17140-7 - DOI - PubMed
    1. Violari A, Cotton MF, Gibb DM, et al. . Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med. 2008;359:2233–2244. http://dx.doi.org/10.1056/NEJMoa0800971 - DOI - PMC - PubMed
    1. Bourne DE, Thompson M, Brody LL, et al. . Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa. AIDS. 2009;23:101–106. http://dx.doi.org/10.1097/QAD.0b013e32831c54bd - DOI - PubMed
    1. National Department of Health National consolidated guidelines for the Prevention of Mother-to-Child Transmission of HIV (PMTCT) and the Management of HIV in Children, Adolescents and Adults. Pretoria: Department of Health; 2014.
    1. Roche® COBAS® AmpliPrep/COBAS® TaqMan HIV-1 Qual Test [package insert]. Branchburg, NJ: Roche; 2007.

LinkOut - more resources