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. 2017 Dec 18;8(1):e00887.
doi: 10.1002/brb3.887. eCollection 2018 Jan.

Food-related salience processing in healthy subjects during word recognition: Fronto-parietal network activation as revealed by independent component analysis

Annette Safi  1 , Christoph Nikendei  1 , Valentin Terhoeven  1 , Matthias Weisbrod  2   3 , Anuradha Sharma  2
Affiliations

Food-related salience processing in healthy subjects during word recognition: Fronto-parietal network activation as revealed by independent component analysis

Annette Safi et al. Brain Behav. .

Abstract

Background: The study aimed to isolate and localize mutually independent cognitive processes evoked during a word recognition task involving food-related and food-neutral words using independent component analysis (ICA) for continuously recorded EEG data. Recognition memory (old/new effect) involves cognitive subcomponents-familiarity and recollection-which may be temporally and spatially dissociated in the brain. Food words may evoke additional attentional salience which may interact with the old/new effect.

Methods: Sixteen satiated female participants undertook a word recognition task consisting of an encoding phase (learning of presented words, 40 food-related and 40 food neutral) and a test phase (recognition of previously learned words and new words). Simultaneously recorded 64-channel EEG data were decomposed into mutually independent components using the Infomax algorithm in EEGLAB. The components were localized using single dipole fitting using a four-shell BESA head model. The resulting (nonartefactual) components with <15% residual variance were clustered across subjects using the kmeans algorithm resulting in five meaningful clusters localized to fronto-parietal regions. Repeated-measures anova was employed to test main effects (old/new and food relevance) and their interaction on cluster time courses.

Results: Early task-relevant old/new effects were localized to the medial frontal gyrus (MFG) and later old/new effects to the right parietal regions (precuneus). Food-related (nontask-relevant) salience effects were localized to bilateral parietal regions (left precuneus and right postcentral gyrus). Food-related salience interacted with task relevance, the old/new effect in MFG being significant only for food-neutral words highlighting central the role of MFG as the converging site of endogenous and exogenous salience inputs.

Conclusion: Our results indicate ICA to be a valid technique to decompose complex neurophysiological signals involving multiple cognitive processes and implicate the fronto-parietal network as an important attentional network for processing salience and task demands.

Keywords: dipole source analysis; electroencephalography; food salience; fronto‐parietal network; independent component analysis; recognition memory.

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Figures

Figure 1
Figure 1
Average scalp maps for cluster centroids of all participants (n = 16) are shown for each obtained cluster
Figure 2
Figure 2
Localizations of the independent component dipoles from individual subjects (n = 16) within every cluster are shown along with the cluster centroid locations (Talairach coordinates)
Figure 3
Figure 3
Figure depicts cluster ERPs (n = 16) of previously seen versus new words time‐locked to the onset of the word stimulus
Figure 4
Figure 4
Figure depicts cluster ERPs (n = 16) of food‐related versus food‐neutral words time‐locked to the onset of the word stimulus
See this image and copyright information in PMC

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