doi: 10.1002/cbdv.201700560.
Epub 2018 May 6.
Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity
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- PMID: 29569369
- DOI: 10.1002/cbdv.201700560
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Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity
Chem Biodivers.
2018 May.
Abstract
Three new compounds (1 - 3), including two euphane type triterpenes, 24,24-dimethoxy-25,26,27-trinoreuphan-3β-ol (1) and (24S)-24-hydroperoxyeupha-8,25-dien-3β-ol (2), and an ent-atisine diterpene, ent-atisane-3α,16α,17-triol (3), were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4 - 11). The structures of compounds (1 - 11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC50 = 1.38 μm).
Keywords: Euphorbia antiquorum; anti-HIV; diterpenes; triterpenes.
© 2018 Wiley-VHCA AG, Zurich, Switzerland.
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