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. 2018 Apr 5;54(29):3609-3612.
doi: 10.1039/C7CC09257A.

DNA nanoclew templated spherical nucleic acids for siRNA delivery

Weimin Ruan  1 , Meng Zheng  1 , Yang An  2 , Yuanyuan Liu  1 , David B Lovejoy  3 , Mingcong Hao  1 , Yan Zou  1 , Albert Lee  3 , Shu Yang  3 , Yiqing Lu  1 , Marco Morsch  3 , Roger Chung  3 , Bingyang Shi  1
Affiliations

DNA nanoclew templated spherical nucleic acids for siRNA delivery

Weimin Ruan et al. Chem Commun (Camb). .

Abstract

A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed a DNA nanoclew (DC). After uptake by cultured cancer cells, SNA nanoparticles release engrafted siRNAs by cleavage of the intracellular Dicer enzyme. Moreover, in vitro experiments reveal that such SNAs demonstrate potent gene knockdown at both mRNA and protein levels, while with negligible cytotoxicity.

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