Review

. 2018 Mar 23;6(2):37.

doi: 10.3390/biomedicines6020037.

Current Strategies to Enhance Anti-Tumour Immunity

Katherine W Cook¹, Lindy G Durrant^{2

3}, Victoria A Brentville⁴

Affiliations

¹ Scancell Limited, Academic Department of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK. katherinecook@scancell.co.uk.
² Scancell Limited, Academic Department of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK. Lindy.Durrant@nottingham.ac.uk.
³ Academic Department of Clinical Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK. Lindy.Durrant@nottingham.ac.uk.
⁴ Scancell Limited, Academic Department of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK. VictoriaBrentville@scancell.co.uk.

PMID: 29570634
PMCID: PMC6027499
DOI: 10.3390/biomedicines6020037

Review

Current Strategies to Enhance Anti-Tumour Immunity

Katherine W Cook et al. Biomedicines. 2018.

. 2018 Mar 23;6(2):37.

doi: 10.3390/biomedicines6020037.

Authors

Katherine W Cook¹, Lindy G Durrant^{2

3}, Victoria A Brentville⁴

Affiliations

¹ Scancell Limited, Academic Department of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK. katherinecook@scancell.co.uk.
² Scancell Limited, Academic Department of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK. Lindy.Durrant@nottingham.ac.uk.
³ Academic Department of Clinical Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK. Lindy.Durrant@nottingham.ac.uk.
⁴ Scancell Limited, Academic Department of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK. VictoriaBrentville@scancell.co.uk.

PMID: 29570634
PMCID: PMC6027499
DOI: 10.3390/biomedicines6020037

Abstract

The interaction of the immune system with cancer is complex, but new approaches are resulting in exciting therapeutic benefits. In order to enhance the immune response to cancer, immune therapies seek to either induce high avidity immune responses to tumour specific antigens or to convert the tumour to a more pro-inflammatory microenvironment. Strategies, including vaccination, oncolytic viruses, and adoptive cell transfer all seek to induce anti-tumour immunity. To overcome the suppressive tumour microenvironment checkpoint inhibitors and modulators of regulatory cell populations have been investigated. This review summarizes the recent advances in immune therapies and discusses the importance of combination therapies in the treatment of cancers.

Keywords: adoptive cell transfer; checkpoint inhibition; immune modulators; immune surveillance; oncolytic viruses; vaccination.

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Conflict of interest statement

Lindy G. Durrant is the joint CEO of Scancell Ltd. has ownership interest (including patents) in Scancell Ltd., is a consultant/advisory board member of Scancell Ltd. All authors are employees of Scancell Ltd.

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Current Strategies to Enhance Anti-Tumour Immunity

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Current Strategies to Enhance Anti-Tumour Immunity

Authors

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Abstract

Conflict of interest statement

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