H₂S to Mitigate Vascular Aging: A SIRT1 Connection

Thiruma V Arumugam¹, Brian K Kennedy²

Affiliations

¹ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
² Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, MD7, 8 Medical Drive, Singapore 117596, Singapore; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: bkennedy@nus.edu.sg.

PMID: 29571000
DOI: 10.1016/j.cell.2018.03.011

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H₂S to Mitigate Vascular Aging: A SIRT1 Connection

Thiruma V Arumugam et al. Cell. 2018.

Free article

. 2018 Mar 22;173(1):8-10.

doi: 10.1016/j.cell.2018.03.011.

Authors

Thiruma V Arumugam¹, Brian K Kennedy²

Affiliations

¹ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
² Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, MD7, 8 Medical Drive, Singapore 117596, Singapore; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: bkennedy@nus.edu.sg.

PMID: 29571000
DOI: 10.1016/j.cell.2018.03.011

Abstract

H₂S is an endogenous gasotransmitter that plays an important role in physiological conditions. In this issue, Das et al. provide evidence that SIRT1-dependent angiogenesis is augmented by H₂S-findings reinforced by Longchamp et al., who demonstrate that H₂S-dependent angiogenesis is triggered by amino acid deprivation.

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Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H₂S Production.
Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. Longchamp A, et al. Cell. 2018 Mar 22;173(1):117-129.e14. doi: 10.1016/j.cell.2018.03.001. Cell. 2018. PMID: 29570992 Free PMC article.
Impairment of an Endothelial NAD⁺-H₂S Signaling Network Is a Reversible Cause of Vascular Aging.
Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Das A, et al. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Cell. 2018. PMID: 29570999 Free PMC article.

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H₂S to Mitigate Vascular Aging: A SIRT1 Connection

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H₂S to Mitigate Vascular Aging: A SIRT1 Connection

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