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Comment
. 2018 Apr 4;26(4):938-940.
doi: 10.1016/j.ymthe.2018.03.005. Epub 2018 Mar 21.

MicroRNA-21 and the Vulnerability of Atherosclerotic Plaques

Temo Barwari  1 , Marieke Rienks  1 , Manuel Mayr  2
Affiliations
Comment

MicroRNA-21 and the Vulnerability of Atherosclerotic Plaques

Temo Barwari et al. Mol Ther. .
No abstract available

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Figures

Figure 1
Figure 1
MicroRNA-21-Based Therapy for Plaque Vulnerability and In-Stent Restenosis Delivery of microRNA-21 (miR-21) mimic to atherosclerotic plaques by ultrasound-targeted microbubble destruction (UTMD) enhances smooth muscle cell proliferation while also steering monocytes toward a reparative, anti-inflammatory phenotype. Conversely, stents coated with miR-21 inhibitor (anti-miR-21) prevent in-stent restenosis through their anti-proliferative effect on smooth muscle cells.
See this image and copyright information in PMC

Comment on

  • Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions.
    Jin H, Li DY, Chernogubova E, Sun C, Busch A, Eken SM, Saliba-Gustafsson P, Winter H, Winski G, Raaz U, Schellinger IN, Simon N, Hegenloh R, Matic LP, Jagodic M, Ehrenborg E, Pelisek J, Eckstein HH, Hedin U, Backlund A, Maegdefessel L. Jin H, et al. Mol Ther. 2018 Apr 4;26(4):1040-1055. doi: 10.1016/j.ymthe.2018.01.011. Epub 2018 Jan 31. Mol Ther. 2018. PMID: 29503197 Free PMC article.

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