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Comment
. 2018 Apr;28(4):389-390.
doi: 10.1038/s41422-018-0030-x.

Ubiquitin-induced phase separation of p62/SQSTM1

Lina Herhaus  1 , Ivan Dikic  2   3
Affiliations
Comment

Ubiquitin-induced phase separation of p62/SQSTM1

Lina Herhaus et al. Cell Res. 2018 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
Cartoon of p62-mediated biomolecular condensate formation. p62 can be membrane-bound or free in the cytosol, where it forms polymers and induces phase separation together with ubiquitin chains. Phase separation results in the formation of liquid-like droplets, which are spherical and can undergo fusion. LC3 family proteins can also be present within these droplets and upon binding to p62 and LC3 lipidation to autophagosomes, the biomolecular condensates can be degraded through autophagy. LC3 family proteins are depicted in orange, p62 polymers in red, ubiquitin chains in green, cargo proteins and the isolation membrane in brown, and biomolecular condensates in blue
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