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. 2018 May;22(4):1625-1630.
doi: 10.1007/s00784-018-2424-z. Epub 2018 Mar 23.

Anatomical locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin-a retrospective study

Florian Alexander Kerker  1 , Werner Adler  2 , Kathrin Brunner  3 , Tobias Moest  1 , Matthias C Wurm  1 , Emeka Nkenke  4 , Friedrich Wilhelm Neukam  1 , Cornelius von Wilmowsky  5
Affiliations

Anatomical locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin-a retrospective study

Florian Alexander Kerker et al. Clin Oral Investig. 2018 May.

Erratum in

Abstract

Objectives: This study aimed to identify anatomical areas where resections of oral squamous cell carcinomas (OSCC) are significantly associated with close or positive margins.

Materials and methods: This retrospective study included 330 patients with a primary OSCC from 2010 to 2015. Patient and tumour data were categorised into three groups by R-status (R0 [clear], ≥ 5 mm, 185 patients [56.06%]; R1 [positive], < 1 mm, 24 patients [7.27%]; and R0 [close], 1-5 mm, 121 patients [36.67%]).

Results: Areas where resections were significantly associated with close or positive margins were the hard palate (p < 0.001), buccal mucosa (p = 0.03), floor of the mouth (p = 0.004), lower alveolar ridge (p = 0.01), retromolar triangle (p = 0.005), and dorsal tongue (p = 0.02).

Conclusions: Anatomical areas were identified in the oral cavity where it is challenging to resect OSCCs with an adequate safety margin.

Clinical relevance: These results may enable surgeons to achieve a postulated safe distance during tumour resection, leading to a survival benefit for patients.

Keywords: Anatomical areas; Oral squamous cell carcinoma; R-status; Resection margin; Safety distance.

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