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. 2018 Aug;22(3):647-655.
doi: 10.1007/s11030-018-9823-6. Epub 2018 Mar 23.

Insect growth regulatory activity of carvacrol-based 1,3,4-thiadiazoles and 1,3,4-oxadiazoles

Suresh D Bagul  1 , Jamatsing D Rajput  1 , Chitra Srivastava  2 , Ratnamala S Bendre  3
Affiliations

Insect growth regulatory activity of carvacrol-based 1,3,4-thiadiazoles and 1,3,4-oxadiazoles

Suresh D Bagul et al. Mol Divers. 2018 Aug.

Abstract

In designing of novel insect growth regulators (IGRs), biologically occurring carvacrol has been structurally modified to thiadiazole and oxadiazole moieties. Two series of carvacrol analogs containing 1,3,4-thiadiazole (VIIIa-e) and 1,3,4-oxadiazole (IXa-e) derivatives are designed and synthesized. Their structures are confirmed by FT-IR, [Formula: see text] NMR, [Formula: see text]C NMR and LC-MS. IGR activity is tested against Spodoptera litura. Several analogs displayed IGR activity against this insect pest. Compounds VIIIe and IXe displayed relatively good IGR activity with [Formula: see text]values 117.43 and 108.83 ppm against Spodoptera litura, respectively. Synthesis, characterization and evaluation of carvacrol-based 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives as potent insect growth regulators (IGRs).

Keywords: 1, 3, 4-Oxadiazole; 1, 3, 4-Thiadiazole; Carvacrol; IGR activity; Spodoptera litura.

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