Comparative Study
doi: 10.1007/BF00365906.
The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity
- PMID: 2957319
- DOI: 10.1007/BF00365906
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Comparative Study
The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity
Immunogenetics.
1987.
Abstract
A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional Fc gamma R investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgG gamma 1/2b and rabbit IgG complexes.
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