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Comparative Study
. 1987;26(3):161-8.
doi: 10.1007/BF00365906.

The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity

P M Hogarth, M L Hibbs, L Bonadonna, B M Scott, E Witort, G A Pietersz, I F McKenzie
Comparative Study

The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity

P M Hogarth et al. Immunogenetics. 1987.

Abstract

A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional Fc gamma R investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgG gamma 1/2b and rabbit IgG complexes.

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References

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