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Comment
. 2018 May;24(5):432-434.
doi: 10.1016/j.molmed.2018.03.003. Epub 2018 Mar 21.

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition

Sara Lovisa  1 , Raghu Kalluri  2
Affiliations
Comment

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition

Sara Lovisa et al. Trends Mol Med. 2018 May.

Abstract

The molecular mechanisms underpinning the process of endothelial-to-mesenchymal transition (EndMT) are mostly unknown. Recently Xiong and colleagues explored for the first time the metabolic changes associated with the activation of the mesenchymal program in endothelial cells, and found that reprogramming of fatty acid oxidation pivotally regulates EndMT.

Keywords: EndMT; endothelial cells; endothelial-to-mesenchymal transition; fatty acid oxidation; metabolism.

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  • A Metabolic Basis for Endothelial-to-Mesenchymal Transition.
    Xiong J, Kawagishi H, Yan Y, Liu J, Wells QS, Edmunds LR, Fergusson MM, Yu ZX, Rovira II, Brittain EL, Wolfgang MJ, Jurczak MJ, Fessel JP, Finkel T. Xiong J, et al. Mol Cell. 2018 Feb 15;69(4):689-698.e7. doi: 10.1016/j.molcel.2018.01.010. Epub 2018 Feb 8. Mol Cell. 2018. PMID: 29429925 Free PMC article.

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