Serum matrix metalloproteinase-9 level as a biomarker for colorectal cancer: a diagnostic meta-analysis

Abstract

Aim: To comprehensively evaluate the diagnostic value of serum matrix metalloproteinase-9 (MMP-9) level for colorectal cancer (CRC).

Methods: Both of the relationships between MMP-9 level and CRC and the diagnostic value were evaluated from 12 eligible papers.

Results: The high MMP-9 level increased CRC risk. The estimated sensitivity and specificity were 69 and 68%, respectively, which signified that the diagnostic value was medium. Diagnostic odds ratio and the area under the receiver operating characteristic curve suggested MMP-9 level has a moderate diagnostic value in CRC. Additionally, the likelihood matrix indicated MMP-9 levels could be considered as a biomarker for the diagnosis of CRC.

Conclusion: Patients with CRC have elevated MMP-9 levels, which is a potential biomarker for CRC diagnosis.

Keywords: colorectal cancer; diagnosis; matrix metalloproteinase-9; meta-analysis.