Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Feb 8:2018:3105138.
doi: 10.1155/2018/3105138. eCollection 2018.

Effect of Hemodialysis on Eye Coats, Axial Length, and Ocular Perfusion Pressure in Patients with Chronic Renal Failure

Ling Wang  1 , Gang Yin  2 , Zhiying Yu  1 , Nan Chen  1 , Dabo Wang  1
Affiliations

Effect of Hemodialysis on Eye Coats, Axial Length, and Ocular Perfusion Pressure in Patients with Chronic Renal Failure

Ling Wang et al. J Ophthalmol. .

Abstract

Purpose: To investigate changes in eye coats, axial length, and ocular perfusion pressure (OPP) in hemodialysis (HD) patients with chronic renal failure (CRF).

Methods: We included HD patients who were diagnosed with CRF in our hospital from January to December 2015. Fifty-two patients met the inclusion criteria; all right eyes were used for observation. Systolic and diastolic blood pressures were recorded to calculate OPP. Approximately 30 minutes before and after HD, we recorded multiple parameters, including lens thickness (LT), axial length of vitreous (VAL), axial length of eye (EAL), ciliary body thickness (CBT), choroidal thickness (CT), and retinal thickness (RT).

Results: After HD, OPP significantly decreased (P < 0.01, F = 7.023) and CBT became significantly thinner (P < 0.01, t = 3.461). CT was significantly thinner and differed among measurement locations (P < 0.01, t = 6.240; P < 0.01, t = 6.169; P < 0.01, t = 3.405, respectively, fovea, nasal, and temporal side 1500 μm beside the fovea). Further, RT thickened and differed among measurement locations (P < 0.05, t = -2.265; P < 0.05, t = -2.624; P < 0.05, t = -2.220, respectively, fovea, nasal, and temporal side 1500 μm beside fovea), whereas LT, VAL, and EAL significantly increased after HD (P < 0.05, t = -2.076; P < 0.01, t = -3.817; P < 0.01, t = -4.010).

Conclusions: HD impacts the thickness of the eye coats and VAL, particularly affecting CBT, CT, and RT. OPP transiently decreases during HD, which may contribute to an ischemic state.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Iris thickness (IT) and ciliary body thickness (CBT) measurements by ultrasound biomicroscopy. IT was 0.43 mm and CBT was 0.61 mm.
Figure 2
Figure 2
Choroid and retinal thickness measurements by optical coherence tomography.
See this image and copyright information in PMC

References

    1. Jindal N., Misra M. Eyeing the complications of hemodialysis in the eye. Hemodialysis International. 2014;18:S48–S51. doi: 10.1111/hdi.12224. - DOI - PubMed
    1. Frezzotti P., Menicacci C., Bagaglia S. A., Mittica P., Toto F., Motolese I. Management of intraocular pressure elevation during hemodialysis of neovascular glaucoma: a case report. BMC Ophthalmology. 2016;16(1):p. 23. doi: 10.1186/s12886-016-0199-z. - DOI - PMC - PubMed
    1. Basu S., Das T., Padhi T. R. Serous retinal detachment and multiple retinal pigment epithelial detachments, following hemodialysis for multi-organ failure. Indian Journal of Ophthalmology. 2010;58(3):261–262. doi: 10.4103/0301-4738.62670. - DOI - PMC - PubMed
    1. Evans R. D., Rosner M. Fellows’ forum: Ocular abnormalities associated with advanced kidney disease and hemodialysis. Seminars in Dialysis. 2005;18(3):252–257. doi: 10.1111/j.1525-139X.2005.18322.x. - DOI - PubMed
    1. El-Sanhouri A. A., Foster R. E., Petersen M. R., et al. Retinal tears after posterior vitreous detachment and vitreous hemorrhage in patients on systemic anticoagulants. Eye. 2011;25(8):1016–1019. doi: 10.1038/eye.2011.106. - DOI - PMC - PubMed

LinkOut - more resources