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. 2018 Mar 23;4(1):00079-2017.
doi: 10.1183/23120541.00079-2017. eCollection 2018 Jan.

Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors

Todd M Tartavoulle  1 , Aryn C Karpinski  2 , Andrew Aubin  3 , Benzi M Kluger  4 , Oliver Distler  5 , Lesley Ann Saketkoo  6   7   8
Affiliations

Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors

Todd M Tartavoulle et al. ERJ Open Res. .

Abstract

Pulmonary hypertension is a potentially fatal disease. Despite pharmacological advances in pulmonary hypertension, fatigue remains common in patients with pulmonary hypertension. A convenience sample of 120 participants at an international patient conference completed the Multidimensional Fatigue Inventory (MFI)-20 scale. Data on New York Heart Association Functional Class, body mass index, oxygen use and medication type/use were also collected. There was a high prevalence of "severe" to "very severe" fatigue for each dimension: General Fatigue (60%), Physical Fatigue (55.8%), Reduced Activity (41.7%), Reduced Motivation (32.5%) and Mental Fatigue (27.5%). The mean±sd overall MFI-20 score was 58±5.1. Dimensions with the highest averaged levels were General Fatigue (13.40±3.61), Physical Fatigue (13.23±3.67) and Reduced Activity (11.33±4.16). Body mass index correlated with higher fatigue scores. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination negatively predicted General Fatigue, Physical Fatigue, Reduced Motivation and Reduced Activity. Triple therapy was a significant predictor of General Fatigue, Physical Fatigue and Reduced Activity. There were no significant predictors of Mental Fatigue. Multidimensional fatigue is common and severe in patients with pulmonary hypertension. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination resulted in lower scores in most fatigue dimensions. Comprehensive assessment of fatigue should be considered in the clinical care of patients with pulmonary hypertension and clinical research to develop formal interventions that target this disabling symptom.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

FIGURE 1
FIGURE 1
Distribution of fatigue severity among the Multidimensional Fatigue Inventory-20 fatigue dimensions.
See this image and copyright information in PMC

References

    1. Frost AE, Badesch DB, Barst RJ, et al. . The changing picture of patients with pulmonary arterial hypertension in the United States: how REVEAL differs from historic and non-US contemporary registries. Chest 2011; 139: 128–137. - PubMed
    1. Swetz KM, Shanafelt TD, Drozdowicz LB, et al. . Symptom burden, quality of life, and attitudes toward palliative care in patients with pulmonary arterial hypertension: results from a cross-sectional patient survey. J Heart Lung Transplant 2012; 31: 1102–1108. - PubMed
    1. Kluger BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology 2013; 80: 409–416. - PMC - PubMed
    1. Saketkoo LA, Grewal HK, Yandle G, et al. . Fatigue may have an impact on functioning and quality of life equal to that of dyspnea in patients with pulmonary hypertension. Am J Respir Crit Care Med 2013; 187: A3306.
    1. Matura LA, McDonough A, Carroll DL. Symptom prevalence, symptom severity, and health-related quality of life among young, middle, and older adults with pulmonary arterial hypertension. Am J Hosp Palliat Care 2016; 33: 214–221. - PubMed

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