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. 2018 Apr 5;54(29):3625-3628.
doi: 10.1039/c8cc01474d.

Synthesis of spiroindolenines by intramolecular ipso-iodocyclization of indol ynones

Pavel Fedoseev  1 , Guglielmo Coppola, Gerardo M Ojeda, Erik V Van der Eycken
Affiliations

Synthesis of spiroindolenines by intramolecular ipso-iodocyclization of indol ynones

Pavel Fedoseev et al. Chem Commun (Camb). .

Abstract

A high-yielding fast spirocyclization of easily available indol ynones has been developed by applying N-iodosuccinimide. The formation of the desired product occurs in an atom-economical way, under mild conditions, instantly after the addition of the reagent. The expected 1,2-rearrangement was not observed. The procedure represents a metal free spirocyclization of indoles with an opportunity for further functionalizations.

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