A Fibroblast Is Not a Fibroblast Is Not a Fibroblast
- PMID: 29579454
- PMCID: PMC6540758
- DOI: 10.1016/j.jid.2017.10.012
A Fibroblast Is Not a Fibroblast Is Not a Fibroblast
Abstract
Fibrosis after injury is a huge public health concern, leading to morbidity, mortality, and expenditure of billions of health care dollars. Recent mouse studies have shown that dermal fibroblasts are heterogeneous. New research using single-cell RNA sequencing to identify major fibroblast populations in humans is paving the way to a better understanding of fibroblast heterogeneity and fibrosis.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
CONFLICT OF INTEREST
The authors state no conflict of interest.
Comment on
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SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin.J Invest Dermatol. 2018 Apr;138(4):802-810. doi: 10.1016/j.jid.2017.09.045. Epub 2017 Dec 6. J Invest Dermatol. 2018. PMID: 29080679 Free PMC article.
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Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations.J Invest Dermatol. 2018 Apr;138(4):811-825. doi: 10.1016/j.jid.2018.01.016. Epub 2018 Jan 31. J Invest Dermatol. 2018. PMID: 29391249 Free PMC article.
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