Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May;71(5):804-810.
doi: 10.1161/HYPERTENSIONAHA.118.10266. Epub 2018 Mar 26.

Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology

Satoru Eguchi  1 , Tatsuo Kawai  2 , Rosario Scalia  2 , Victor Rizzo  2
Affiliations
Review

Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology

Satoru Eguchi et al. Hypertension. 2018 May.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Signal transduction mechanism of EGFR transactivation by AngII in vascular smooth muscle cells leading to vascular remodeling. PTK; protein tyrosine kinase, PI3K; Phosphoinositide 3-kinase, p70S6K; p70 S6 kinase. Please note that in addition to this cascade both classical and novel pathways have been shown to contribute to AngII-mediated vascular remodeling (reviewed in detail recently in the reference ).
Figure 2
Figure 2
Potential roles of ADAM17 activation in cardiovascular pathophysiology. In addition to EGFR transactivation, ADAM17 may contribute to endothelial dysfunction and insulin resistance by producing TNFα and inhibiting ACE2.
See this image and copyright information in PMC

References

    1. Karnik SS, Unal H, Kemp JR, Tirupula KC, Eguchi S, Vanderheyden PM, Thomas WG International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected] Pharmacol Rev. 2015;67:754–819. - PMC - PubMed
    1. Kawai T, Forrester SJ, O’Brien S, Baggett A, Rizzo V, Eguchi S. AT1 receptor signaling pathways in the cardiovascular system. Pharmacol Res. 2017;125:4–13. - PMC - PubMed
    1. Bumpus FM, Catt KJ, Chiu AT, DeGasparo M, Goodfriend T, Husain A, Peach MJ, Taylor DG, Jr, Timmermans PB. Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research. Hypertension. 1991;17:720–1. - PubMed
    1. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52:415–72. - PubMed
    1. Sasaki K, Yamano Y, Bardhan S, Iwai N, Murray JJ, Hasegawa M, Matsuda Y, Inagami T. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature. 1991;351:230–3. - PubMed

Publication types

Substances