doi: 10.1007/BF00917013.
Helper activity by human large granular lymphocytes in in vitro immunoglobulin synthesis
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- PMID: 2958493
- DOI: 10.1007/BF00917013
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Helper activity by human large granular lymphocytes in in vitro immunoglobulin synthesis
J Clin Immunol.
1987 Sep.
Abstract
In the present study we have examined the effect of human large granular lymphocytes (LGL) from healthy donors on Ig synthesis by autologous B lymphocytes. The results showed that this cell population has a consistent helper activity in pokeweed mitogen-activated cultures even when added at very low numbers. LGL can mediate their effect by secreting soluble helper factors capable of modulating B-cell responses as evidenced by the enhancement of IgG and IgM production by supernatants obtained from LGL cultures. Preincubation with interferon gamma further potentiated the helper activity by LGL.
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