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Comment
. 2018 Mar 26;44(6):657-658.
doi: 10.1016/j.devcel.2018.03.006.

piRNA Rules of Engagement

Joshua M Svendsen  1 , Taiowa A Montgomery  2
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Free article
Comment

piRNA Rules of Engagement

Joshua M Svendsen et al. Dev Cell. .
Free article

Abstract

piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while protective mechanisms prevent silencing self-genes.

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