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Editorial
. 2018 Mar 26;19(4):986.
doi: 10.3390/ijms19040986.

Role of the Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

Sharon DeMorrow  1   2
Affiliations
Editorial

Role of the Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

Sharon DeMorrow. Int J Mol Sci. .

Abstract

The Hypothalamic-Pituitary-adrenal (HPA) axis describes a complex set of positive and negative feedback influences between the hypothalamus, pituitary gland, and adrenal gland.[...].

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Conflict of interest statement

The author declares no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

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References

    1. Joseph D.N., Whirledge S. Stress and the hpa axis: Balancing homeostasis and fertility. Int. J. Mol. Sci. 2017;18:2224. doi: 10.3390/ijms18102224. - DOI - PMC - PubMed
    1. Kalyani M., Callahan P., Janik J.M., Shi H. Effects of pup separation on stress response in postpartum female rats. Int. J. Mol. Sci. 2017;18:1370. doi: 10.3390/ijms18071370. - DOI - PMC - PubMed
    1. Schiffner R., Rodriguez-Gonzalez G.L., Rakers F., Nistor M., Nathanielsz P.W., Daneva T., Schwab M., Lehmann T., Schmidt M. Effects of late gestational fetal exposure to dexamethasone administration on the postnatal hypothalamus-pituitary-adrenal axis response to hypoglycemia in pigs. Int. J. Mol. Sci. 2017;18:2241. doi: 10.3390/ijms18112241. - DOI - PMC - PubMed
    1. Klimes-Dougan B., Klingbeil D.A., Houri A., Cullen K.R., Gunlicks-Stoessel M., August G. A pilot study of stress system activation in children enrolled in a targeted prevention program: Implications for personalization. Int. J. Mol. Sci. 2018;19:361. doi: 10.3390/ijms19020361. - DOI - PMC - PubMed
    1. Chong L.S., Thai M., Cullen K.R., Lim K.O., Klimes-Dougan B. Cortisol awakening response, internalizing symptoms, and life satisfaction in emerging adults. Int. J. Mol. Sci. 2017;18:2501. doi: 10.3390/ijms18122501. - DOI - PMC - PubMed

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