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. 2018 Mar 27;19(1):51.
doi: 10.1186/s12931-018-0754-7.

Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review

Alessandro G Fois  1   2 , Panagiotis Paliogiannis  3 , Salvatore Sotgia  3 , Arduino A Mangoni  4 , Elisabetta Zinellu  5 , Pietro Pirina  6   5 , Ciriaco Carru  3 , Angelo Zinellu  3
Affiliations

Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review

Alessandro G Fois et al. Respir Res. .

Abstract

Introduction: Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative stress is one of the main pathogenic pathways in IPF. The aim of this systematic review was to describe the type of markers of oxidative stress identified in different biological specimens and the effects of antioxidant therapies in patients with IPF.

Methods: We conducted a systematic search of publications listed in electronic databases (Pubmed, Web of Science, Scopus and Google Scholar) from inception to October 2017. Two investigators independently reviewed all identified articles to determine eligibility.

Results: After a substantial proportion of the initially identified articles (n = 554) was excluded because they were duplicates, abstracts, irrelevant, or did not meet the selection criteria, we identified 30 studies. In each study, we critically appraised the type, site (systemic vs. local, e.g. breath, sputum, expired breath condensate, epithelial lining fluid, bronchoalveolar lavage, and lung tissue specimens), and method used for measuring the identified oxidative stress biomarkers. Furthermore, the current knowledge on antioxidant therapies in IPF was summarized.

Conclusions: A number of markers of oxidative stress, with individual advantages and limitations, have been described in patients with IPF. Nevertheless, trials of antioxidant treatments have been unable to demonstrate consistent benefits, barring recent pharmacogenomics data suggesting different results in specific genotype subgroups of patients with IPF.

Keywords: Antioxidant; Idiopathic pulmonary fibrosis; Lung; Oxidant; Oxidative stress.

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Conflict of interest statement

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Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Oxidative stress plays a critical role in the pathogenesis of IPF through: a) promoting inflammation by increasing production of cytokines and growth factor, which causes b) fragmentation of extracellular matrix, increased myofibroblastic differentiation, fibrogenesis and epithelialization; c) as a consequence of DNA damage and p53 activation, ROS promote apoptosis of airway epithelial cells resulting in an impaired ability to regenerate alveolar epithelium. These alterations contribute to the progression of pulmonary fibrosis
Fig. 2
Fig. 2
Flow chart showing the literature search and selection. Specific reasons for exclusion of studies are also shown
See this image and copyright information in PMC

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