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. 2018 Apr 20;21(4):327-332.
doi: 10.3779/j.issn.1009-3419.2018.04.21.

[Individualized Comprehensive Therapy for the Lung Cancer Patients with HIV Infection]

[Article in Chinese]
Lin Wang  1 , Yanzheng Song  1
Affiliations

[Individualized Comprehensive Therapy for the Lung Cancer Patients with HIV Infection]

[Article in Chinese]
Lin Wang et al. Zhongguo Fei Ai Za Zhi. .

Abstract
in English, Chinese

Background: To observe clinical features, clinical stagings, types ofpathology, treatment options and clinical effects of patients suffer from HIV infection combined with lung cancer, and also to provide guidance for individualized comprehensive treatment of HIV combined with lung cancer.

Methods: Through the retrospective analysis of 53 cases of HIV merger of lung cancer patients admitted in our department, 47 cases of non-small cell lung cancer (NSCLC), 6 cases of small cell lung cancer (SCLC), 24 cases accepted surgery combined chemotherapy, 22 patients with simple chemotherapy, 7 cases give up treatment; 28 cases are in stages I-III, 25 cases are in stage IV; 24 patients received combined chemotherapy in 28 patients with stages I-III, 2 cases gave up treatment, 2 cases with severe chronic obstructive pulmonary disease (COPD) could not tolerate chemotherapy plus surgery. According to the situation of patients before highly active anti-retroviral therapy (HAART) treatment, patients who received HAART before treatment were divided into observation group (n=27), patients who did not receive HAART were divided into control group (n=19). The survival and the independent influencing factors between the two groups were analyzed.

Results: Among the 53 HIV infected cases a toal of 46 patients received treatment among 53 cases of treatment in patients with lung cancer merger of HIV, there are no differences of 1 year survival rate, 2 years survival rate between observation group and control group; patients in I-III phase 1 year survival rate was 76.0%, 2 years survival rate was 60.0%. Patients in IV phase 1 year survival rate was 13.6%, 2 years survival rate was 0%. 24 patients with surgery combined chemotherapy 1 year survival rate was 83.3%, 2 years survival rate was 62.5%; 22 cases treated with simple chemotherapy 1 year survival rate was 18.0%, 2 years survival rate was 0%.

Conclusions: HIV merger in patients with lung cancer can improve the patients survival rate after different individualized comprehensive treatment, early surgery with combined chemotherapy has remarkable effect.

背景与目的 观察HIV合并肺癌患者临床特征、临床分期、病理学类型、治疗方案及临床效果，为HIV合并肺癌的个体化综合治疗提供指导。方法 通过回顾性分析我科收治的53例HIV合并肺癌患者，其中47例非小细胞肺癌（non-small cell lung cancer, NSCLC），6例小细胞肺癌（small cell lung cancer, SCLC），24例接受手术联合化疗，22例接受单纯化疗，7例放弃治疗；其中I期-III期28例，IV期25例；28例I期-III期患者中手术联合化疗24例，2例放弃治疗，2例合并严重慢性阻塞性肺疾病无法耐受手术接受化疗。根据患者治疗前高效抗逆转录病毒治疗（highly active anti-retroviral therapy, HAART）治疗情况，将治疗前接受HAART治疗的视为观察组（n=27），未接受HAART治疗患者放入对照组（n=19）。对比两组生存率情况，分析患者不同治疗方案的生存率及其独立影响因素。结果 53例HIV合并肺癌患者中接受治疗的46例，观察组与对照组1年生存率、2年生存率无组间差异；I期-III期生存期患者1年生存率为76.0%，2年生存率为60.0%。IV期患者1年生存率为13.6%，2年生存率为0%。24例手术联合化疗患者1年生存率83.3%，2年生存率62.5%；22例接受单纯化疗的患者1年生存率18.0%，2年生存率为0%。结论 HIV合并肺癌患者经不同的个体化综合治疗可以提高患者生存率，早期手术联合化疗效果显著。.

Keywords: Chemotherapy; Human immunodeficiency virus; Individualized; Lung neoplasms; Surgical treatment; Survival rate.

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两组生存单因素分析 Single-factor analysis of survival rate in two groups
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